Phage therapy to treat cystic fibrosis Burkholderia cepacia complex lung infections: perspectives and challenges

complex is a cause of serious lung infections in people with cystic fibrosis, exhibiting extremely high levels of antimicrobial resistance. These infections are difficult to treat and are associated with high morbidity and mortality. With a notable lack of new antibiotic classes currently in develop...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in microbiology 2024-10, Vol.15, p.1476041
Main Authors: Canning, Jack S, Laucirica, Daniel R, Ling, Kak-Ming, Nicol, Mark P, Stick, Stephen M, Kicic, Anthony
Format: Article
Language:English
Subjects:
antimicrobial resistance
bacteriophage
Burkholderia
cystic fibrosis
phage therapy
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:complex is a cause of serious lung infections in people with cystic fibrosis, exhibiting extremely high levels of antimicrobial resistance. These infections are difficult to treat and are associated with high morbidity and mortality. With a notable lack of new antibiotic classes currently in development, exploring alternative antimicrobial strategies for complex is crucial. One potential alternative seeing renewed interest is the use of bacteriophage (phage) therapy. This review summarises what is currently known about complex in cystic fibrosis, as well as challenges and insights for using phages to treat complex lung infections.
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2024.1476041