A predictive molecular signature consisting of lncRNAs associated with cellular senescence for the prognosis of lung adenocarcinoma

The role of long noncoding RNAs (lncRNAs) has been verified by more and more researches in recent years. However, there are few reports on cellular senescence-associated lncRNAs in lung adenocarcinoma (LUAD). Therefore, to explore the prognostic effect of lncRNAs in LUAD, 279 cellular senescence-rel...

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Bibliographic Details
Published in:PloS one 2023-06, Vol.18 (6), p.e0287132-e0287132
Main Authors: Liu, Anbang, Wang, Xiaohuai, Hu, Liu, Yan, Dongqing, Yin, Yin, Zheng, Hongjie, Liu, Gengqiu, Zhang, Junhang, Li, Yun
Format: Article
Language:English
Subjects:
Adenocarcinoma
Biology and life sciences
Biomarkers
Cancer
Cancer therapies
Cell cycle
Cellular Senescence - genetics
Chemotherapy
Cytokines
Datasets
Gene expression
Genes
Genetic aspects
Genomes
Genomics
Health aspects
Humans
Identification and classification
Liver cancer
Lung
Lung cancer
Lung cancer, Non-small cell
Lung Neoplasms - genetics
Lungs
Medical prognosis
Medicine and Health Sciences
Metastasis
Molecular modelling
Non-coding RNA
Oncology, Experimental
Physical Sciences
Prognosis
Regression analysis
Research and Analysis Methods
Risk groups
RNA
RNA, Long Noncoding - genetics
Senescence
Software
Thyroid gland
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Summary:The role of long noncoding RNAs (lncRNAs) has been verified by more and more researches in recent years. However, there are few reports on cellular senescence-associated lncRNAs in lung adenocarcinoma (LUAD). Therefore, to explore the prognostic effect of lncRNAs in LUAD, 279 cellular senescence-related genes, survival information and clinicopathologic parameters were derived from the CellAge database and The Cancer Genome Atlas (TCGA) database. Then, we constructed a novel cellular senescence-associated lncRNAs predictive signature (CS-ALPS) consisting of 6 lncRNAS (AC026355.1, AL365181.2, AF131215.5, C20orf197, GAS6-AS1, GSEC). According to the median of the risk score, 480 samples were divided into high-risk and low-risk groups. Furthermore, the clinicopathological and biological functions, immune characteristics and common drug sensitivity were analyzed between two risk groups. In conclusion, the CS-ALPS can independently forecast the prognosis of LUAD, which reveals the potential molecular mechanism of cellular senescence-associated lncRNAs, and provides appropriate strategies for the clinical treatment of patients with LUAD.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0287132