Nitrite Triggers Reprogramming of the Oral Polymicrobial Metabolome by a Commensal Streptococcus

Commensal streptococci regulate health and homeostasis within oral polymicrobial communities. Remarkably, high salivary nitrite concentrations have also been associated with improved health in the oral cavity. We previously demonstrated that nitrite assists hydrogen peroxide-producing oral commensal...

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Bibliographic Details
Published in:Frontiers in cellular and infection microbiology 2022-03, Vol.12, p.833339-833339
Main Authors: Huffines, Joshua T, Stoner, Sara N, Baty, Joshua J, Scoffield, Jessica A
Format: Article
Language:English
Subjects:
bacterial competition
Cellular and Infection Microbiology
Metabolome
Mouth
nitrite
Nitrites
oral commensal
polymicrobial
reactive nitrogen species
Streptococcus
Symbiosis - physiology
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Summary:Commensal streptococci regulate health and homeostasis within oral polymicrobial communities. Remarkably, high salivary nitrite concentrations have also been associated with improved health in the oral cavity. We previously demonstrated that nitrite assists hydrogen peroxide-producing oral commensal streptococci in regulating homeostasis the generation of reactive nitrogen species (RNS), which have antimicrobial activity on oral pathogens. However, it is unknown how nitrite and commensal streptococci work in concert to influence the metabolome of oral polymicrobial communities. In this study, we report that nitrite aids commensal streptococci in the inhibition of multi-kingdom pathogens that reside in distinct oral niches, which supports commensal dominance. More importantly, we show that commensal streptococci utilize nitrite to drive the metabolic signature of multispecies biofilms in a manner that supports commensal metabolism and resistance to RNS, and restricts metabolic processes that are required for pathogen virulence. Taken together, our study provides insight into how commensal streptococci use nitrite to trigger shifts in the oral polymicrobial metabolome to support health and homeostasis.
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2022.833339