A bone-specific adipogenesis pathway in fat-free mice defines key origins and adaptations of bone marrow adipocytes with age and disease

Bone marrow adipocytes accumulate with age and in diverse disease states. However, their origins and adaptations in these conditions remain unclear, impairing our understanding of their context-specific endocrine functions and relationship with surrounding tissues. In this study, by analyzing bone a...

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Bibliographic Details
Published in:eLife 2021-08, Vol.10
Main Authors: Zhang, Xiao, Robles, Hero, Magee, Kristann L, Lorenz, Madelyn R, Wang, Zhaohua, Harris, Charles A, Craft, Clarissa S, Scheller, Erica L
Format: Article
Language:English
Subjects:
Adaptation
Adipocytes
Adipocytes - metabolism
Adipocytes - physiology
Adipogenesis
Adipogenesis - physiology
Adiponectin
Adipose tissue
Adipose Tissue - metabolism
Adipose Tissue - physiology
Age
Age Factors
aging
Animals
Bone and Bones - metabolism
Bone and Bones - physiology
Bone marrow
Bone Marrow - metabolism
Bone Marrow - physiology
bone marrow adipocyte
Bone Marrow Cells - metabolism
Bone Marrow Cells - physiology
Cell Biology
Cell Differentiation
Cytokines
Fat-free
Female
Fibroblasts
Hematopoiesis - physiology
Hemopoiesis
Lipids
Male
Metabolism
Mice
Mice, Inbred C57BL
Mice, Transgenic
Osteoblasts - metabolism
Osteoblasts - physiology
progenitor cells
Proteins
Vertebrae
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Summary:Bone marrow adipocytes accumulate with age and in diverse disease states. However, their origins and adaptations in these conditions remain unclear, impairing our understanding of their context-specific endocrine functions and relationship with surrounding tissues. In this study, by analyzing bone and adipose tissues in the lipodystrophic 'fat-free' mouse, we define a novel, secondary adipogenesis pathway that relies on the recruitment of adiponectin-negative stromal progenitors. This pathway is unique to the bone marrow and is activated with age and in states of metabolic stress in the fat-free mouse model, resulting in the expansion of bone marrow adipocytes specialized for lipid storage with compromised lipid mobilization and cytokine expression within regions traditionally devoted to hematopoiesis. This finding further distinguishes bone marrow from peripheral adipocytes and contributes to our understanding of bone marrow adipocyte origins, adaptations, and relationships with surrounding tissues with age and disease.
ISSN:2050-084X
2050-084X
DOI:10.7554/eLife.66275