Comparative Analysis of Anal Colposcopy with Histology in the Follow-Up of Patients under Treatment for Anal Condyloma

Abstract Objectives  To compare morphological abnormalities on anal colposcopy against histology to determine anal high-grade squamous intraepithelial lesions (HSILs). Methods  This is a retrospective data assessment of HIV-negative and HIV-positive patients undergoing outpatient follow-up. The samp...

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Published in:Journal of Coloproctology 2022-03, Vol.42 (1), p.063-067
Main Authors: Manzione, Thiago da Silveira, Nadal, Sidney Roberto, Gonçalves, Antônio José
Format: Article
Language:English
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anal colposcopy
anal condyloma
anal high-grade squamous intraepithelial lesion
GASTROENTEROLOGY & HEPATOLOGY
high-resolution anoscopy
Original Article
SURGERY
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Nadal, Sidney Roberto
Gonçalves, Antônio José
description Abstract Objectives  To compare morphological abnormalities on anal colposcopy against histology to determine anal high-grade squamous intraepithelial lesions (HSILs). Methods  This is a retrospective data assessment of HIV-negative and HIV-positive patients undergoing outpatient follow-up. The sample comprised 54 patients presenting acetowhite lesions on anal colposcopy. Acetowhite lesions were classified according to their morphology into punctation, verrucous, mosaic, ulcerated, or hypervascularized, and biopsies of these specimens were classified as anal HSIL, low-grade squamous intraepithelial lesion (LSIL), or normal. The data were analyzed using SPSS for Windows version 13.0 (SPSS Inc., Chicago, IL, USA). The results were analyzed using the nonparametric Mann-Whitney test, the Fisher exact test and the chi-squared parametric test. A 95% confidence interval (CI) was used and a level of significance 
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Methods  This is a retrospective data assessment of HIV-negative and HIV-positive patients undergoing outpatient follow-up. The sample comprised 54 patients presenting acetowhite lesions on anal colposcopy. Acetowhite lesions were classified according to their morphology into punctation, verrucous, mosaic, ulcerated, or hypervascularized, and biopsies of these specimens were classified as anal HSIL, low-grade squamous intraepithelial lesion (LSIL), or normal. The data were analyzed using SPSS for Windows version 13.0 (SPSS Inc., Chicago, IL, USA). The results were analyzed using the nonparametric Mann-Whitney test, the Fisher exact test and the chi-squared parametric test. A 95% confidence interval (CI) was used and a level of significance &lt; 5% was adopted for all statistical tests. Results  Fifty-four patients (50 males, 80% HIV + ) with biopsied acetowhite lesions were assessed. There were 31 punctation lesions, 1 classified as HSIL (3.2%; 95%CI: 0–40.0), 17 verrucous lesions, 3 HSIL (17.7%; 95%CI: 0–10.7), and 1 ulcerated, classified as HSIL (100%), and 4 mosaic and 1 atypical vessel lesion, all classified as LSIL. The results showed no association of presence of anal HSIL with positivity for HIV infection or with counts above or below 500/µl in HIV+ patients. Statistical analysis was performed using the Mann-Whitney nonparametric test, the Fisher exact test, and the chi-squared parametric test. Conclusion  The comparison of morphological findings on anal colposcopy against histology revealed no morphological pattern suggesting anal HSIL.</description><identifier>ISSN: 2237-9363</identifier><identifier>ISSN: 2317-6423</identifier><identifier>EISSN: 2317-6423</identifier><identifier>DOI: 10.1055/s-0041-1739299</identifier><language>eng</language><publisher>Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil: Thieme Revinter Publicações Ltda</publisher><subject>anal colposcopy ; anal condyloma ; anal high-grade squamous intraepithelial lesion ; GASTROENTEROLOGY &amp; HEPATOLOGY ; high-resolution anoscopy ; Original Article ; SURGERY</subject><ispartof>Journal of Coloproctology, 2022-03, Vol.42 (1), p.063-067</ispartof><rights>Sociedade Brasileira de Coloproctologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon.</rights><rights>This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2929-54ab3618395bbe4443d7881f68e30d499516874e7bc302876a0c702fb65ac1ae3</cites><orcidid>0000-0003-1914-0129 ; 0000-0003-4376-2059 ; 0000-0002-8238-4559</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,24150,27924,27925</link.rule.ids></links><search><creatorcontrib>Manzione, Thiago da Silveira</creatorcontrib><creatorcontrib>Nadal, Sidney Roberto</creatorcontrib><creatorcontrib>Gonçalves, Antônio José</creatorcontrib><title>Comparative Analysis of Anal Colposcopy with Histology in the Follow-Up of Patients under Treatment for Anal Condyloma</title><title>Journal of Coloproctology</title><addtitle>J. Coloproctol. (Rio J.)</addtitle><description>Abstract Objectives  To compare morphological abnormalities on anal colposcopy against histology to determine anal high-grade squamous intraepithelial lesions (HSILs). Methods  This is a retrospective data assessment of HIV-negative and HIV-positive patients undergoing outpatient follow-up. The sample comprised 54 patients presenting acetowhite lesions on anal colposcopy. Acetowhite lesions were classified according to their morphology into punctation, verrucous, mosaic, ulcerated, or hypervascularized, and biopsies of these specimens were classified as anal HSIL, low-grade squamous intraepithelial lesion (LSIL), or normal. The data were analyzed using SPSS for Windows version 13.0 (SPSS Inc., Chicago, IL, USA). The results were analyzed using the nonparametric Mann-Whitney test, the Fisher exact test and the chi-squared parametric test. A 95% confidence interval (CI) was used and a level of significance &lt; 5% was adopted for all statistical tests. Results  Fifty-four patients (50 males, 80% HIV + ) with biopsied acetowhite lesions were assessed. There were 31 punctation lesions, 1 classified as HSIL (3.2%; 95%CI: 0–40.0), 17 verrucous lesions, 3 HSIL (17.7%; 95%CI: 0–10.7), and 1 ulcerated, classified as HSIL (100%), and 4 mosaic and 1 atypical vessel lesion, all classified as LSIL. The results showed no association of presence of anal HSIL with positivity for HIV infection or with counts above or below 500/µl in HIV+ patients. Statistical analysis was performed using the Mann-Whitney nonparametric test, the Fisher exact test, and the chi-squared parametric test. Conclusion  The comparison of morphological findings on anal colposcopy against histology revealed no morphological pattern suggesting anal HSIL.</description><subject>anal colposcopy</subject><subject>anal condyloma</subject><subject>anal high-grade squamous intraepithelial lesion</subject><subject>GASTROENTEROLOGY &amp; HEPATOLOGY</subject><subject>high-resolution anoscopy</subject><subject>Original Article</subject><subject>SURGERY</subject><issn>2237-9363</issn><issn>2317-6423</issn><issn>2317-6423</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>0U6</sourceid><sourceid>DOA</sourceid><recordid>eNp1kUtP3TAQhaOqSEWULWv_AVO_4scSXUFBQipSYW1NHIdr5MSRHUD593W4FFYsLI9GPp9nzmmaM0rOKWnbXwUTIiimihtmzLfmmHGqsBSMf6814wobLvmP5rSU0BHGlGqF4MfNyy6NM2RYwotHFxPEtYSC0vBWo12KcyouzSt6DcseXYeypJgeVxQmtOw9ukoxplf8MG-Su0rx01LQ89T7jO6zh2WsDTSk_J839WtMI_xsjgaIxZ--3yfNw9Xl_e4a3_75fbO7uMWO1T1wK6Djkmpu2q7zok7cK63pILXnpBfGtFRqJbzqHCdMKwnEKcKGTrbgKHh-0twcuH2CJzvnMEJebYJg3xopP1rIS3DR294wSUAPqpetcESDEr0mTjogwhBQlXV-YBUXfEz2KT3nulSxfzd_7eYvq84SQmg9kn8KXE6lZD98DECJ3VKzxW6p2ffUqgAfBMs--NF__vDF-39hq5VY</recordid><startdate>20220301</startdate><enddate>20220301</enddate><creator>Manzione, Thiago da Silveira</creator><creator>Nadal, Sidney Roberto</creator><creator>Gonçalves, Antônio José</creator><general>Thieme Revinter Publicações Ltda</general><general>Sociedade Brasileira de Coloproctologia</general><scope>0U6</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>GPN</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-1914-0129</orcidid><orcidid>https://orcid.org/0000-0003-4376-2059</orcidid><orcidid>https://orcid.org/0000-0002-8238-4559</orcidid></search><sort><creationdate>20220301</creationdate><title>Comparative Analysis of Anal Colposcopy with Histology in the Follow-Up of Patients under Treatment for Anal Condyloma</title><author>Manzione, Thiago da Silveira ; Nadal, Sidney Roberto ; Gonçalves, Antônio José</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2929-54ab3618395bbe4443d7881f68e30d499516874e7bc302876a0c702fb65ac1ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>anal colposcopy</topic><topic>anal condyloma</topic><topic>anal high-grade squamous intraepithelial lesion</topic><topic>GASTROENTEROLOGY &amp; HEPATOLOGY</topic><topic>high-resolution anoscopy</topic><topic>Original Article</topic><topic>SURGERY</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Manzione, Thiago da Silveira</creatorcontrib><creatorcontrib>Nadal, Sidney Roberto</creatorcontrib><creatorcontrib>Gonçalves, Antônio José</creatorcontrib><collection>Thieme Connect Journals Open Access</collection><collection>CrossRef</collection><collection>SciELO</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Journal of Coloproctology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Manzione, Thiago da Silveira</au><au>Nadal, Sidney Roberto</au><au>Gonçalves, Antônio José</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative Analysis of Anal Colposcopy with Histology in the Follow-Up of Patients under Treatment for Anal Condyloma</atitle><jtitle>Journal of Coloproctology</jtitle><addtitle>J. Coloproctol. (Rio J.)</addtitle><date>2022-03-01</date><risdate>2022</risdate><volume>42</volume><issue>1</issue><spage>063</spage><epage>067</epage><pages>063-067</pages><issn>2237-9363</issn><issn>2317-6423</issn><eissn>2317-6423</eissn><abstract>Abstract Objectives  To compare morphological abnormalities on anal colposcopy against histology to determine anal high-grade squamous intraepithelial lesions (HSILs). Methods  This is a retrospective data assessment of HIV-negative and HIV-positive patients undergoing outpatient follow-up. The sample comprised 54 patients presenting acetowhite lesions on anal colposcopy. Acetowhite lesions were classified according to their morphology into punctation, verrucous, mosaic, ulcerated, or hypervascularized, and biopsies of these specimens were classified as anal HSIL, low-grade squamous intraepithelial lesion (LSIL), or normal. The data were analyzed using SPSS for Windows version 13.0 (SPSS Inc., Chicago, IL, USA). The results were analyzed using the nonparametric Mann-Whitney test, the Fisher exact test and the chi-squared parametric test. A 95% confidence interval (CI) was used and a level of significance &lt; 5% was adopted for all statistical tests. Results  Fifty-four patients (50 males, 80% HIV + ) with biopsied acetowhite lesions were assessed. There were 31 punctation lesions, 1 classified as HSIL (3.2%; 95%CI: 0–40.0), 17 verrucous lesions, 3 HSIL (17.7%; 95%CI: 0–10.7), and 1 ulcerated, classified as HSIL (100%), and 4 mosaic and 1 atypical vessel lesion, all classified as LSIL. The results showed no association of presence of anal HSIL with positivity for HIV infection or with counts above or below 500/µl in HIV+ patients. Statistical analysis was performed using the Mann-Whitney nonparametric test, the Fisher exact test, and the chi-squared parametric test. Conclusion  The comparison of morphological findings on anal colposcopy against histology revealed no morphological pattern suggesting anal HSIL.</abstract><cop>Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil</cop><pub>Thieme Revinter Publicações Ltda</pub><doi>10.1055/s-0041-1739299</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-1914-0129</orcidid><orcidid>https://orcid.org/0000-0003-4376-2059</orcidid><orcidid>https://orcid.org/0000-0002-8238-4559</orcidid><oa>free_for_read</oa></addata></record>
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subjects anal colposcopy
anal condyloma
anal high-grade squamous intraepithelial lesion
GASTROENTEROLOGY & HEPATOLOGY
high-resolution anoscopy
Original Article
SURGERY
title Comparative Analysis of Anal Colposcopy with Histology in the Follow-Up of Patients under Treatment for Anal Condyloma
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