Pre-diabetes and diabetic neuropathy are associated with low serum levels of interleukin-9

Background Interleukin-9 (IL-9) is a cytokine that has recently been proposed to be associated with type 2 diabetes mellitus (T2DM) risk, but the role it plays in the development of pre-diabetes (PD) and diabetic neuropathy (DN) is unknown. Therefore, this study analyzed serum IL-9 levels in individ...

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Bibliographic Details
Published in:Beni-Suef University journal of basic and applied sciences 2023-12, Vol.12 (1), p.75-8, Article 75
Main Authors: Khalaf, Noorulhuda F., Al-rikabi, Aaiad H., Salman, Isam N., Saihood, Yahya D., Nassurat, Shahad W., Jasim, Ola H., Ad’hiah, Ali H.
Format: Article
Language:English
Subjects:
Asthma
Biomarkers
Body mass index
Chronic illnesses
Cytokines
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetic neuropathy
Disease
Females
Glucose
Health care
Hyperglycemia
Inflammation
Insulin resistance
Interleukin 9
Interleukins
Laboratories
Medicine
Medicine & Public Health
Metabolism
Odds ratio
Pathogenesis
Pre-diabetes
Receiver operating characteristic curve
Serum levels
Tumor necrosis factor-TNF
Type 2 diabetes mellitus
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Summary:Background Interleukin-9 (IL-9) is a cytokine that has recently been proposed to be associated with type 2 diabetes mellitus (T2DM) risk, but the role it plays in the development of pre-diabetes (PD) and diabetic neuropathy (DN) is unknown. Therefore, this study analyzed serum IL-9 levels in individuals with PD (n = 89), T2DM patients without DN (n = 66), T2DM patients with DN (n = 21), and non-diabetic controls (n = 84) using an ELISA kit . Results Serum IL-9 levels (median and interquartile range) were significantly lower in the PD (18.9 [12.6–22.1] pg/mL; probability [ p ] 
ISSN:2314-8543
2314-8535
2314-8543
DOI:10.1186/s43088-023-00412-6