Role of CA125 in the Diagnosis of Acute Appendicitis

Aim: Acute appendicitis (AA) is the most common surgical emergency in the world, and its diagnosis is mainly dependent on clinical findings. Recently, secretion of CA125 from peritoneal cells due to inflammatory stimulus has been shown. The aim of this study was to evaluate the relation between CA25...

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Bibliographic Details
Published in:Eurasian journal of emergency medicine 2017-06, Vol.16 (2), p.62-64
Main Authors: Sevinc, Baris, Turan, Ersin, Kurku, Huseyin, Karahan, Omer
Format: Article
Language:English
Subjects:
Acute appendicitis
Appendicitis
Blood tests
CA-125
diagnosis
Emergency medical care
Medical diagnosis
Proteins
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Summary:Aim: Acute appendicitis (AA) is the most common surgical emergency in the world, and its diagnosis is mainly dependent on clinical findings. Recently, secretion of CA125 from peritoneal cells due to inflammatory stimulus has been shown. The aim of this study was to evaluate the relation between CA25 levels and AA.Materials and Methods: In this prospective trial, CA125 levels were measured. Group 1 consisted histopathologically approved AA cases. Group 2 consisted healthy individuals.Results: Seventy-four cases (37 AA and 37 healthy individuals) were included in the study. In the AA group, the mean CA125 level was 9.8±9.3 U/mL, and in the control group, it was 4.6±1.5 U/mL. In Pearson correlation analysis, the CA125 level had a positive correlation with AA (r=0.371, p=0.001).Conclusion: Recent studies demonstrate that CA125 can help distinguish patients with or without AA. CA125 levels can be used as a marker of AA in cases with clinical doubt.
ISSN:2149-5807
2149-6048
DOI:10.5152/eajem.2017.83703