The Mechanisms of Sevoflurane-Induced Neuroinflammation

Sevoflurane is one of the most commonly used inhaled anesthetics due to its low blood gas coefficient, fast onset, low airway irritation, and aromatic smell. However, recent studies have reported that sevoflurane exposure may have deleterious effects on cognitive function. Although neuroinflammation...

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Bibliographic Details
Published in:Frontiers in aging neuroscience 2021-08, Vol.13, p.717745-717745
Main Authors: Huang, Xiangfei, Ying, Jun, Yang, Danying, Fang, Pu, Wang, Xifeng, Zhou, Bin, Zhang, Lieliang, Fang, Yang, Yu, Wen, Liu, Xing, Zhen, Qingcui, Hua, Fuzhou
Format: Article
Language:English
Subjects:
Alzheimer's disease
Anesthesia
Anesthetics
blood–brain barrier
cholinergic neurotransmission
Cognitive ability
Cytokines
gut microbiota
Immune system
Inflammation
Intestinal microflora
Irritation
Microbiota
microglia
Neurodegeneration
neuroinflammation
Neurons
Neuroscience
Neurotoxicity
Neurotransmission
Older people
Parkinson's disease
Peptides
Phosphorylation
Sevoflurane
Tumor necrosis factor-TNF
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Summary:Sevoflurane is one of the most commonly used inhaled anesthetics due to its low blood gas coefficient, fast onset, low airway irritation, and aromatic smell. However, recent studies have reported that sevoflurane exposure may have deleterious effects on cognitive function. Although neuroinflammation was most widely mentioned among the established mechanisms of sevoflurane-induced cognitive dysfunction, its upstream mechanisms have yet to be illustrated. Thus, we reviewed the relevant literature and discussed the most mentioned mechanisms, including the modulation of the microglial function, blood–brain barrier (BBB) breakdown, changes in gut microbiota, and ease of cholinergic neurotransmission to help us understand the properties of sevoflurane, providing us new perspectives for the prevention of sevoflurane-induced cognitive impairment.
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2021.717745