Targeting deubiquitinating enzymes in cancer stem cells

Cancer stem cells (CSCs) are rare but accounted for tumor initiation, progression, metastasis, relapse and therapeutic resistance. Ubiquitination and deubiquitination of stemness-related proteins are essential for CSC maintenance and differentiation, even leading to execute various stem cell fate ch...

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Bibliographic Details
Published in:Cancer cell international 2017-11, Vol.17 (1), p.101-101, Article 101
Main Authors: Lei, Hu, Shan, Huizhuang, Wu, Yingli
Format: Article
Language:English
Subjects:
Apoptosis
Brain cancer
Breast cancer
Cancer
Cancer stem cells
Cancer therapies
Cell fate
CSCs
Deubiquitinating enzymes
Dismantling
Enzymes
Lung cancer
Metastases
Multiple myeloma
Proteins
Review
Stem cells
Transcription factors
Ubiquitin
Ubiquitination
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Summary:Cancer stem cells (CSCs) are rare but accounted for tumor initiation, progression, metastasis, relapse and therapeutic resistance. Ubiquitination and deubiquitination of stemness-related proteins are essential for CSC maintenance and differentiation, even leading to execute various stem cell fate choices. Deubiquitinating enzymes (DUBs), specifically disassembling ubiquitin chains, are important to maintain the balance between ubiquitination and deubiquitination. In this review, we have focused on the DUBs regulation of stem cell fate determination. For example, we discuss deubiquitinase inhibition may lead stem cell transcription factors and CSCs-related protein degradation. Also, CSCs microenvironment is regulated by DUBs activity. Our review provides a new insight into DUBs activity by emphasizing their cellular role in regulating stem cell fate and illustrates the opportunities for the application of DUBs inhibitors in the CSC-targeted therapy.
ISSN:1475-2867
1475-2867
DOI:10.1186/s12935-017-0472-0