Immune profiling of the progression of a BALB/c mouse aerosol infection by Burkholderia pseudomallei and the therapeutic implications of targeting HMGB1

Highlights • Burkholderia pseudomallei infection by an airborne route was modelled in mice, and groups were culled for further analysis as the infection progressed. • We found differences in the cytokines released by the different infected organs. • We found that the damage-associated molecular patt...

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Bibliographic Details
Published in:International journal of infectious diseases 2015-11, Vol.40 (C), p.1-8
Main Authors: Laws, Thomas R, Clark, Graeme C, D’Elia, Riccardo V
Format: Article
Language:English
Subjects:
Aerosols
Animals
Burkholderia pseudomallei
Cytokines
HMGB1
HMGB1 Protein - genetics
HMGB1 Protein - metabolism
Infection
Infectious Disease
Interferon-gamma - therapeutic use
Liver - immunology
Melioidosis - immunology
Melioidosis - metabolism
Mice
Mice, Inbred BALB C
Pulmonary/Respiratory
Signal Transduction
Spleen - microbiology
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Summary:Highlights • Burkholderia pseudomallei infection by an airborne route was modelled in mice, and groups were culled for further analysis as the infection progressed. • We found differences in the cytokines released by the different infected organs. • We found that the damage-associated molecular pattern HMGB1 was released during infection. • HMGB1 was removed from mice using an antibody during a B. pseudomallei infection. • HMGB1 knockdown reduced the expression of some pro-inflammatory cytokines and reduced bacterial load, but did not increase survival measurably.
ISSN:1201-9712
1878-3511
DOI:10.1016/j.ijid.2015.09.003