Neuroprotective potential of Cordia dichotoma in Parkinson's syndrome induced by haloperidol: An animal study

• Published in: Saudi pharmaceutical journal 2023-10, Vol.31 (10), p.101791-101791, Article 101791
• Main Authors: Bhavani, Keserla, Muthukumar, A., Almuqbil, Mansour, Das, Kuntal, V., Yakshitha, Almadani, Moneer E., Alshehri, Ahmed, Alghamdi, Adel, Hussain, Syed Arif, Alamer, Bader Hussain, Abdulrahman Jibreel, Ebtesam, Rabbani, Syed Imam, Alosaimi, Turki Mohammed, Alharbi, Waleed Farah, Aldosari, Sultan Mohammed, Basheeruddin Asdaq, Syed Mohammed
• Format: Article
• Language: English
• Subjects: Antioxidants; Biochemical markers; Cordia dichotoma; Haloperidol; Histopathology; Neuroprotective; Original; Parkinson’s diseases
• ISSN: 1319-0164; 2213-7475
• DOI: 10.1016/j.jsps.2023.101791

Parkinson’s disease (PD) is one of the major neurodegenerative disorders and the prevalence is expected to increaseduring the next couple of decades. There is a need for safe and effective therapeutic regimen that can effectively manage this neurotoxicity. The leaves and several other parts ofCordia dichotomaare known to possess number of medicinal properties. The purpose of this study was to examine the neuroprotective role ofCordia dichotomain an experimental model of haloperidol-induced P.D. Five groups of rats were randomly assigned into different groups. Intraperitoneal haloperidol 1 mg/kg was given to the inducer group and 0.5% CMC to the normal control. The reference standard was syndopa 10 mg/kg, p.o., and the test group animals receivedC. dichotoma'sethanolic extract at 200 and 400 mg/kg orally for one week. Rats exposed to haloperidol were assessed for behavioral, neurochemical, and histopathological parameters. C. dichotoma leaves extract dose-dependently increased behavioral activity and muscle coordination. The extract at 400 mg/kg was found to increase significantly (P