Diagnostic and Prognostic Role of Extracellular Vesicles in Pancreatic Cancer: Current Evidence and Future Perspectives

Pancreatic cancer is one of the most aggressive tumors, with a dismal prognosis due to poor detection rates at early stages, rapid progression, post-surgical complications, and limited effectiveness of conventional oncologic therapies. There are no consistently reliable biomarkers or imaging modalit...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-01, Vol.24 (1), p.885
Main Authors: Nicoletti, Alberto, Negri, Marcantonio, Paratore, Mattia, Vitale, Federica, Ainora, Maria Elena, Nista, Enrico Celestino, Gasbarrini, Antonio, Zocco, Maria Assunta, Zileri Dal Verme, Lorenzo
Format: Article
Language:English
Subjects:
biomarkers
Biomarkers, Tumor
early diagnosis
extracellular vesicles
Extracellular Vesicles - pathology
Humans
microRNA
pancreatic cancer
Pancreatic Hormones
Pancreatic Neoplasms
Pancreatic Neoplasms - diagnosis
Pancreatic Neoplasms - pathology
Prognosis
proteomics
Review
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Summary:Pancreatic cancer is one of the most aggressive tumors, with a dismal prognosis due to poor detection rates at early stages, rapid progression, post-surgical complications, and limited effectiveness of conventional oncologic therapies. There are no consistently reliable biomarkers or imaging modalities to accurately diagnose, classify, and predict the biological behavior of this tumor. Therefore, it is imperative to develop new and improved strategies to detect pancreatic lesions in the early stages of cancerization with greater sensitivity and specificity. Extracellular vesicles, including exosome and microvesicles, are membrane-coated cellular products that are released in the outer environment. All cells produce extracellular vesicles; however, this process is enhanced by inflammation and tumorigenesis. Based on accumulating evidence, extracellular vesicles play a crucial role in pancreatic cancer progression and chemoresistance. Moreover, they may represent potential biomarkers and promising therapy targets. The aim of the present review is to review the current evidence on the role of extracellular vesicles in pancreatic cancer.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24010885