Investigation of new inflammatory biomarkers in patients with brucella

• Published in: PloS one 2024-02, Vol.19 (2), p.e0297550-e0297550
• Main Authors: Canpolat Erkan, Revşa Evin, Tekin, Recep
• Format: Article
• Language: English
• Subjects: Analysis; B cells; Biological markers; Biology and Life Sciences; Blood; Brucellosis; Care and treatment; Diagnosis; Inflammation; Medical examination; Medical research; Medicine and Health Sciences; Medicine, Experimental; Research and Analysis Methods
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0297550

Delayed diagnosis and inadequate treatment of infectious and inflammatory diseases, such as Brucella, lead to high rates of mortality and morbidity. The aim of our study was to investigate the association between serum levels of apelin, presepsin, and irisin with inflammation, laboratory parameters, and blood culture in patients with brucella. This prospective case-control study involves 30 patients with brucellosis and 30 healthy, matched control subjects. Thirty patients who were diagnosed with brucellosis were aged ≥ 18 years. Blood samples were taken from the patients on the first day they were diagnosed with brucellosis. The values of irisin, presepsin, and apelin were studied. In addition, blood samples were also taken from 30 healthy individuals for the control group. Irisin, presepsin, and apelin values that were measured in the patients on the first day were compared with those values measured in the control group. The sex and age statuses of the subjects are matched among the groups. The levels of irisin were significantly higher in patients with brucellosis compared to the control group (p