The Immune Microenvironment in Brain Metastases of Non-Small Cell Lung Cancer

Brain metastasis of non-small cell lung cancer is associated with poor survival outcomes and poses rough clinical challenges. At the era of immunotherapy, it is urgent to perform a comprehensive study uncovering the specific immune microenvironment of brain metastases of NSCLC. The immune microenvir...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in oncology 2021-07, Vol.11, p.698844-698844
Main Authors: Luo, Lumeng, Liu, Peiyi, Zhao, Kuaile, Zhao, Weixin, Zhang, Xiaofei
Format: Article
Language:English
Subjects:
brain metastases
brain metastases of non-small cell lung cancer
immune microenvironment
immune therapeutics
non-small cell lung cancer
Oncology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Brain metastasis of non-small cell lung cancer is associated with poor survival outcomes and poses rough clinical challenges. At the era of immunotherapy, it is urgent to perform a comprehensive study uncovering the specific immune microenvironment of brain metastases of NSCLC. The immune microenvironment of brain is distinctly different from microenvironments of extracranial lesions. In this review, we summarized the process of brain metastases across the barrier and revealed that brain is not completely immune-privileged. We comprehensively described the specific components of immune microenvironment for brain metastases such as central nervous system-derived antigen-presenting cells, microglia and astrocytes. Besides, the difference of immune microenvironment between brain metastases and primary foci of lung was particularly demonstrated.
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2021.698844