A Case with ZNF198-FGFR1 Gene Rearrangement Presenting as Acute Eosinophil Myeloid Leukemia

A previously healthy 47-year-old Chinese man presented in January 2009 with extreme fatigue,fever,and night sweats.Hepatomegaly （palpable,2 cm in the right hypochondrium） and splenomegaly （palpable,2 cm in the left hypochondrium） were identified,and axillary lymph nodes were swollen.A laboratory inv...

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Bibliographic Details
Published in:Chinese medical journal 2015-01, Vol.128 (1), p.131-132
Main Authors: Chao, Hongying, Zhou, Min, Zhang, Ri
Format: Article
Language:English
Subjects:
Acute Myeloid Leukemia
Eosinophilia
Imatinib
ZNF198-FGFR1
Blood
Blood platelets
Cancer genetics
Care and treatment
Case studies
Chemotherapy
Clinical Practice
Diagnosis
DNA-Binding Proteins - genetics
Fibroblasts
Gene expression
Gene therapy
Genetic aspects
Growth factors
Health aspects
Hematology
Hospitals
Humans
Kinases
Laboratories
Leukemia
Leukemia, Myeloid, Acute - genetics
Male
Middle Aged
Myeloid leukemia
Patients
Receptor, Fibroblast Growth Factor, Type 1 - genetics
Risk factors
Signal transduction
Stem cells
Transcription Factors - genetics
Tumors
嗜酸性粒细胞
基因重排
急性
案例
白血病
肝肿大
血小板计数
血红蛋白
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Summary:A previously healthy 47-year-old Chinese man presented in January 2009 with extreme fatigue,fever,and night sweats.Hepatomegaly （palpable,2 cm in the right hypochondrium） and splenomegaly （palpable,2 cm in the left hypochondrium） were identified,and axillary lymph nodes were swollen.A laboratory investigation showed a white blood cell （WBC） count of 39.8 × 10^9/L with eosinophils 52% （absolute eosinophil count of 20.7 × 10^9/L）,hemoglobin level of 14.9 g/dl and platelet count of 50.0 × 10^9/L.
ISSN:0366-6999
2542-5641
DOI:10.4103/0366-6999.147863