Detection and Treatment of Helicobacter pylori: Problems and Advances

Helicobacter pylori (H. pylori) infection is chronic and etiologically linked to gastric cancer (GC) derived from gastric epithelium. The potential mechanism is complex, covering chronic inflammation, epithelial senescence, NF-κB activation, the cytotoxin-associated gene A protein translocation, and...

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Bibliographic Details
Published in:Gastroenterology research and practice 2022-10, Vol.2022, p.4710964-10
Main Authors: Yang, Hang, Guan, Liwen, Hu, Bing
Format: Article
Language:English
Subjects:
Antibiotics
Antigens
Antiulcer drugs
Biopsy
Biosensors
Care and treatment
Clinical medicine
Disease prevention
Drug resistance
Endoscopy
Family medical history
Health aspects
Helicobacter pylori
Histology
Infection
Infections
Metronidazole
Patient compliance
Patients
Review
Rifabutin
Serology
Stomach cancer
Tetracycline
Tetracyclines
VOCs
Volatile organic compounds
Wu, K. C
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Summary:Helicobacter pylori (H. pylori) infection is chronic and etiologically linked to gastric cancer (GC) derived from gastric epithelium. The potential mechanism is complex, covering chronic inflammation, epithelial senescence, NF-κB activation, the cytotoxin-associated gene A protein translocation, and related abnormal signaling pathways. In clinical practice, the test-and-treat strategy, endoscopy-based strategy, and (family-based) screen-and-treat strategy are recommended to detect H. pylori and prevent GC. It has been demonstrated that the decreasing annual incidence of GC is largely attributable to the management of H. pylori. This study reviews the current clinical practice of H. pylori on the detection and eradication, alternative treatment strategies, and related problems and advances, and hopes to contribute to the better clinical management of H. pylori.
ISSN:1687-6121
1687-630X
DOI:10.1155/2022/4710964