Autoimmune hemolytic anemia and giant cell hepatitis: Report of three infants

Giant cell hepatitis associated with direct Coombs’ test-positive hemolytic anemia is a rare condition of childhood and the pathogenesis remains unclear. An autoimmune activation and loss of self-tolerance in these patients may be the underlying pathology related to the response of some of the patie...

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Bibliographic Details
Published in:Turkish journal of haematology 2010-12, Vol.27 (4), p.308-313
Main Authors: Şule Ünal, Barış Kuşkonmaz, Necati Balamtekin, Gökhan Baysoy, Selin Aytaç Elmas, Diclehan Orhan, Gülsev Kale, Aysel Yüce, Figen Gürakan, Fatma Gümrük, Mualla Çetin
Format: Article
Language:English
Subjects:
direct Coombs’ test
Giant cell hepatitis
immune hemolytic anemia
rituximab
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Summary:Giant cell hepatitis associated with direct Coombs’ test-positive hemolytic anemia is a rare condition of childhood and the pathogenesis remains unclear. An autoimmune activation and loss of self-tolerance in these patients may be the underlying pathology related to the response of some of the patients to immunosuppressive treatment. Herein, we report the clinical presentation and course of three consecutive patients with this rare condition. We conclude that serum ferritin at diagnosis may be used for prediction of the outcome.
ISSN:1300-7777
1308-5263