Autoimmune hemolytic anemia and giant cell hepatitis: Report of three infants

Giant cell hepatitis associated with direct Coombs’ test-positive hemolytic anemia is a rare condition of childhood and the pathogenesis remains unclear. An autoimmune activation and loss of self-tolerance in these patients may be the underlying pathology related to the response of some of the patie...

Full description

Saved in:
Bibliographic Details
Published in:Turkish journal of haematology 2010-12, Vol.27 (4), p.308-313
Main Authors: Şule Ünal, Barış Kuşkonmaz, Necati Balamtekin, Gökhan Baysoy, Selin Aytaç Elmas, Diclehan Orhan, Gülsev Kale, Aysel Yüce, Figen Gürakan, Fatma Gümrük, Mualla Çetin
Format: Article
Language:English
Subjects:
direct Coombs’ test
Giant cell hepatitis
immune hemolytic anemia
rituximab
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 313
container_issue 4
container_start_page 308
container_title Turkish journal of haematology
container_volume 27
creator Şule Ünal
Barış Kuşkonmaz
Necati Balamtekin
Gökhan Baysoy
Selin Aytaç Elmas
Diclehan Orhan
Gülsev Kale
Aysel Yüce
Figen Gürakan
Fatma Gümrük
Mualla Çetin
description Giant cell hepatitis associated with direct Coombs’ test-positive hemolytic anemia is a rare condition of childhood and the pathogenesis remains unclear. An autoimmune activation and loss of self-tolerance in these patients may be the underlying pathology related to the response of some of the patients to immunosuppressive treatment. Herein, we report the clinical presentation and course of three consecutive patients with this rare condition. We conclude that serum ferritin at diagnosis may be used for prediction of the outcome.
format article
fullrecord <record><control><sourceid>doaj</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_d968035edd104aecb687a9efd1fcab46</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_d968035edd104aecb687a9efd1fcab46</doaj_id><sourcerecordid>oai_doaj_org_article_d968035edd104aecb687a9efd1fcab46</sourcerecordid><originalsourceid>FETCH-doaj_primary_oai_doaj_org_article_d968035edd104aecb687a9efd1fcab463</originalsourceid><addsrcrecordid>eNqtTcFuwjAUi9CQ6IB_yA9USlsILTc0DW2HXSbu0aN5gYeSpkrSQ_-eCO0T5ost27IXrKga0Zb7WjZvLy3KQ8aKvcf4EKJuZS0K9nOakifnpgH5HZ23c6Kew4COIJPmN4Ih8R6tzfkIiRLFI__F0YfEveHpHhA5DSbX4oYtDdiI2z9es-_z5-Xjq9QeHmoM5CDMygOpl-HDTUHIhxaV7mQrmj1qXYkdYH-V7QE6NLoyPVx3svnPrSdj-1rq</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Autoimmune hemolytic anemia and giant cell hepatitis: Report of three infants</title><source>Directory of Open Access Journals (DOAJ)</source><source>Publicly Available Content Database</source><creator>Şule Ünal ; Barış Kuşkonmaz ; Necati Balamtekin ; Gökhan Baysoy ; Selin Aytaç Elmas ; Diclehan Orhan ; Gülsev Kale ; Aysel Yüce ; Figen Gürakan ; Fatma Gümrük ; Mualla Çetin</creator><creatorcontrib>Şule Ünal ; Barış Kuşkonmaz ; Necati Balamtekin ; Gökhan Baysoy ; Selin Aytaç Elmas ; Diclehan Orhan ; Gülsev Kale ; Aysel Yüce ; Figen Gürakan ; Fatma Gümrük ; Mualla Çetin</creatorcontrib><description>Giant cell hepatitis associated with direct Coombs’ test-positive hemolytic anemia is a rare condition of childhood and the pathogenesis remains unclear. An autoimmune activation and loss of self-tolerance in these patients may be the underlying pathology related to the response of some of the patients to immunosuppressive treatment. Herein, we report the clinical presentation and course of three consecutive patients with this rare condition. We conclude that serum ferritin at diagnosis may be used for prediction of the outcome.</description><identifier>ISSN: 1300-7777</identifier><identifier>EISSN: 1308-5263</identifier><language>eng</language><publisher>Galenos Publishing House</publisher><subject>direct Coombs’ test ; Giant cell hepatitis ; immune hemolytic anemia ; rituximab</subject><ispartof>Turkish journal of haematology, 2010-12, Vol.27 (4), p.308-313</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2102</link.rule.ids></links><search><creatorcontrib>Şule Ünal</creatorcontrib><creatorcontrib>Barış Kuşkonmaz</creatorcontrib><creatorcontrib>Necati Balamtekin</creatorcontrib><creatorcontrib>Gökhan Baysoy</creatorcontrib><creatorcontrib>Selin Aytaç Elmas</creatorcontrib><creatorcontrib>Diclehan Orhan</creatorcontrib><creatorcontrib>Gülsev Kale</creatorcontrib><creatorcontrib>Aysel Yüce</creatorcontrib><creatorcontrib>Figen Gürakan</creatorcontrib><creatorcontrib>Fatma Gümrük</creatorcontrib><creatorcontrib>Mualla Çetin</creatorcontrib><title>Autoimmune hemolytic anemia and giant cell hepatitis: Report of three infants</title><title>Turkish journal of haematology</title><description>Giant cell hepatitis associated with direct Coombs’ test-positive hemolytic anemia is a rare condition of childhood and the pathogenesis remains unclear. An autoimmune activation and loss of self-tolerance in these patients may be the underlying pathology related to the response of some of the patients to immunosuppressive treatment. Herein, we report the clinical presentation and course of three consecutive patients with this rare condition. We conclude that serum ferritin at diagnosis may be used for prediction of the outcome.</description><subject>direct Coombs’ test</subject><subject>Giant cell hepatitis</subject><subject>immune hemolytic anemia</subject><subject>rituximab</subject><issn>1300-7777</issn><issn>1308-5263</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNqtTcFuwjAUi9CQ6IB_yA9USlsILTc0DW2HXSbu0aN5gYeSpkrSQ_-eCO0T5ost27IXrKga0Zb7WjZvLy3KQ8aKvcf4EKJuZS0K9nOakifnpgH5HZ23c6Kew4COIJPmN4Ih8R6tzfkIiRLFI__F0YfEveHpHhA5DSbX4oYtDdiI2z9es-_z5-Xjq9QeHmoM5CDMygOpl-HDTUHIhxaV7mQrmj1qXYkdYH-V7QE6NLoyPVx3svnPrSdj-1rq</recordid><startdate>20101201</startdate><enddate>20101201</enddate><creator>Şule Ünal</creator><creator>Barış Kuşkonmaz</creator><creator>Necati Balamtekin</creator><creator>Gökhan Baysoy</creator><creator>Selin Aytaç Elmas</creator><creator>Diclehan Orhan</creator><creator>Gülsev Kale</creator><creator>Aysel Yüce</creator><creator>Figen Gürakan</creator><creator>Fatma Gümrük</creator><creator>Mualla Çetin</creator><general>Galenos Publishing House</general><scope>DOA</scope></search><sort><creationdate>20101201</creationdate><title>Autoimmune hemolytic anemia and giant cell hepatitis: Report of three infants</title><author>Şule Ünal ; Barış Kuşkonmaz ; Necati Balamtekin ; Gökhan Baysoy ; Selin Aytaç Elmas ; Diclehan Orhan ; Gülsev Kale ; Aysel Yüce ; Figen Gürakan ; Fatma Gümrük ; Mualla Çetin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-doaj_primary_oai_doaj_org_article_d968035edd104aecb687a9efd1fcab463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>direct Coombs’ test</topic><topic>Giant cell hepatitis</topic><topic>immune hemolytic anemia</topic><topic>rituximab</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Şule Ünal</creatorcontrib><creatorcontrib>Barış Kuşkonmaz</creatorcontrib><creatorcontrib>Necati Balamtekin</creatorcontrib><creatorcontrib>Gökhan Baysoy</creatorcontrib><creatorcontrib>Selin Aytaç Elmas</creatorcontrib><creatorcontrib>Diclehan Orhan</creatorcontrib><creatorcontrib>Gülsev Kale</creatorcontrib><creatorcontrib>Aysel Yüce</creatorcontrib><creatorcontrib>Figen Gürakan</creatorcontrib><creatorcontrib>Fatma Gümrük</creatorcontrib><creatorcontrib>Mualla Çetin</creatorcontrib><collection>Directory of Open Access Journals (DOAJ)</collection><jtitle>Turkish journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Şule Ünal</au><au>Barış Kuşkonmaz</au><au>Necati Balamtekin</au><au>Gökhan Baysoy</au><au>Selin Aytaç Elmas</au><au>Diclehan Orhan</au><au>Gülsev Kale</au><au>Aysel Yüce</au><au>Figen Gürakan</au><au>Fatma Gümrük</au><au>Mualla Çetin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Autoimmune hemolytic anemia and giant cell hepatitis: Report of three infants</atitle><jtitle>Turkish journal of haematology</jtitle><date>2010-12-01</date><risdate>2010</risdate><volume>27</volume><issue>4</issue><spage>308</spage><epage>313</epage><pages>308-313</pages><issn>1300-7777</issn><eissn>1308-5263</eissn><abstract>Giant cell hepatitis associated with direct Coombs’ test-positive hemolytic anemia is a rare condition of childhood and the pathogenesis remains unclear. An autoimmune activation and loss of self-tolerance in these patients may be the underlying pathology related to the response of some of the patients to immunosuppressive treatment. Herein, we report the clinical presentation and course of three consecutive patients with this rare condition. We conclude that serum ferritin at diagnosis may be used for prediction of the outcome.</abstract><pub>Galenos Publishing House</pub><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1300-7777
ispartof Turkish journal of haematology, 2010-12, Vol.27 (4), p.308-313
issn 1300-7777
1308-5263
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_d968035edd104aecb687a9efd1fcab46
source Directory of Open Access Journals (DOAJ); Publicly Available Content Database
subjects direct Coombs’ test
Giant cell hepatitis
immune hemolytic anemia
rituximab
title Autoimmune hemolytic anemia and giant cell hepatitis: Report of three infants
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T19%3A04%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-doaj&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Autoimmune%20hemolytic%20anemia%20and%20giant%20cell%20hepatitis:%20Report%20of%20three%20infants&rft.jtitle=Turkish%20journal%20of%20haematology&rft.au=%C5%9Eule%20%C3%9Cnal&rft.date=2010-12-01&rft.volume=27&rft.issue=4&rft.spage=308&rft.epage=313&rft.pages=308-313&rft.issn=1300-7777&rft.eissn=1308-5263&rft_id=info:doi/&rft_dat=%3Cdoaj%3Eoai_doaj_org_article_d968035edd104aecb687a9efd1fcab46%3C/doaj%3E%3Cgrp_id%3Ecdi_FETCH-doaj_primary_oai_doaj_org_article_d968035edd104aecb687a9efd1fcab463%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true