Transcriptome‐wide association analysis identified candidate susceptibility genes for nasopharyngeal carcinoma

• Published in: Cancer communications (London, England) England), 2022-09, Vol.42 (9), p.887-891
• Main Authors: He, Yong‐Qiao, Xue, Wen‐Qiong, Li, Dan‐Hua, Wang, Tong‐Min, Mai, Zhi‐Ming, Yang, Da‐Wei, Deng, Chang‐Mi, Liao, Ying, Zhang, Wen‐Li, Xiao, Ruo‐Wen, Luo, Luting, Diao, Hua, Tong, Xiating, Wu, Yanxia, Zhang, Jiang‐Bo, Zhou, Ting, Li, Xi‐Zhao, Zhang, Pei‐Fen, Zheng, Xiao‐Hui, Zhang, Shao‐Dan, Hu, Ye‐Zhu, Tang, Minzhong, Zheng, Yuming, Cai, Yonglin, Chang, Ellen T., Zhang, Zhe, Huang, Guangwu, Cao, Su‐Mei, Liu, Qing, Feng, Lin, Sun, Ying, Lung, Maria Li, Adami, Hans‐Olov, Ye, Weimin, Lam, Tai‐Hing, Jia, Wei‐Hua
• Format: Article
• Language: English
• Subjects: Antigens; Cancer; Encyclopedias; Epstein-Barr virus; Gene expression; Genomes; Hepatitis B; Hepatitis C; Infections; Letter to the Editor; Letters to the Editor; Lymphocytes; Medicin och hälsovetenskap; Ontology
• ISSN: 2523-3548; 2523-3548
• DOI: 10.1002/cac2.12317

Abbreviations EBV Epstein-Barr virus GO gene ontology GWAS genome-wide association analysis HBV hepatitis B virus HCV hepatitis C virus HLA human leukocyte antigen KEGG Kyoto encyclopedia of genes and genomes LD linkage disequilibrium NPC nasopharyngeal carcinoma PIP posterior inclusion probability QC quality control TWAS transcriptome-wide association analysis ZEBRA BamHI Z EBV replication activator Dear Editor, Nasopharyngeal carcinoma (NPC) is a common malignancy in East and Southeast Asia, especially in South China. [...]using the cis-regulated expression in addition to genetic variants to explore NPC susceptibility genes could be promising and reasonable for mechanistic and functional inference. Herein, we integrated genome and transcriptome data of 89 nasopharyngeal tumor tissues and investigated the associations between predicted gene expression levels and NPC risk using multicenter GWAS data involving 4506 NPC cases and 5384 cancer-free subjects (defined as controls) from South China. HLA-DOB may impact viral clearance capacity and persistent infection of hepatitis B virus (HBV) and hepatitis C virus (HCV) [ 9]. Since EBV reactivation with elevated EBV DNA load or antibodies was observed at the preclinical phase of NPC, we hypothesized that HLA class II genes, especially HLA-DQB1and HLA-DOB, participate in the early stage of NPC tumorigenesis by influencing EBV infection.