Versatility of Induced Pluripotent Stem Cells (iPSCs) for Improving the Knowledge on Musculoskeletal Diseases

Induced pluripotent stem cells (iPSCs) represent an unlimited source of pluripotent cells capable of differentiating into any cell type of the body. Several studies have demonstrated the valuable use of iPSCs as a tool for studying the molecular and cellular mechanisms underlying disorders affecting...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-08, Vol.21 (17), p.6124
Main Authors: Sanjurjo-Rodríguez, Clara, Castro-Viñuelas, Rocío, Piñeiro-Ramil, María, Rodríguez-Fernández, Silvia, Fuentes-Boquete, Isaac, Blanco, Francisco J, Díaz-Prado, Silvia
Format: Article
Language:English
Subjects:
Aging
bone
Cartilage
Cell Differentiation
Disease
EVs
Humans
Induced Pluripotent Stem Cells - cytology
iPSCs
Muscles
Muscular dystrophy
Musculoskeletal diseases
Musculoskeletal Diseases - therapy
Organ Specificity
Pluripotency
Regeneration (physiology)
Regenerative Medicine
Researchers
Review
Stem Cell Transplantation
Stem cells
Tissue engineering
Translational Medical Research
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Summary:Induced pluripotent stem cells (iPSCs) represent an unlimited source of pluripotent cells capable of differentiating into any cell type of the body. Several studies have demonstrated the valuable use of iPSCs as a tool for studying the molecular and cellular mechanisms underlying disorders affecting bone, cartilage and muscle, as well as their potential for tissue repair. Musculoskeletal diseases are one of the major causes of disability worldwide and impose an important socio-economic burden. To date there is neither cure nor proven approach for effectively treating most of these conditions and therefore new strategies involving the use of cells have been increasingly investigated in the recent years. Nevertheless, some limitations related to the safety and differentiation protocols among others remain, which humpers the translational application of these strategies. Nonetheless, the potential is indisputable and iPSCs are likely to be a source of different types of cells useful in the musculoskeletal field, for either disease modeling or regenerative medicine. In this review, we aim to illustrate the great potential of iPSCs by summarizing and discussing the in vitro tissue regeneration preclinical studies that have been carried out in the musculoskeletal field by using iPSCs.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21176124