Anti-proliferative effect of methanolic extract of Gracilaria tenuistipitata on oral cancer cells involves apoptosis, DNA damage, and oxidative stress

Methanolic extracts of Gracilaria tenuistipitata (MEGT) were obtained from the edible red algae. Previously, we found that water extract of G. tenuistipitata was able to modulate oxidative stress-induced DNA damage and its related cellular responses. In this study, the methanol extraction product ME...

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Bibliographic Details
Published in:BMC complementary and alternative medicine 2012-08, Vol.12 (1), p.142-142, Article 142
Main Authors: Yeh, Chi-Chen, Yang, Jing-Iong, Lee, Jin-Ching, Tseng, Chao-Neng, Chan, Ya-Ching, Hseu, You-Cheng, Tang, Jen-Yang, Chuang, Li-Yeh, Huang, Hurng-Wern, Chang, Fang-Rong, Chang, Hsueh-Wei
Format: Article
Language:English
Subjects:
Algae
Analysis
Annexin V
Apoptosis
Apoptosis - drug effects
Cancer
Cancer cells
Cancer therapies
Cell culture
Cell Line, Tumor
Cell Proliferation - drug effects
Colleges & universities
Cytotoxicity
Deoxyribonucleic acid
DNA
DNA damage
DNA Damage - drug effects
Drinking water
Ethanol
Flow cytometry
Genetic aspects
Glutathione
Gracilaria - chemistry
Gracilaria tenuistipitata
Growth Inhibitors - pharmacology
Humans
Membrane potential
Metabolites
Methanol
Mitochondria
Mitochondrial membrane potential
Molecular weight
Mortality
Mouth cancer
Mouth Neoplasms - drug therapy
Mouth Neoplasms - genetics
Mouth Neoplasms - metabolism
Mouth Neoplasms - physiopathology
Natural products
Oral cancer
oral squamous cell carcinoma
Oxidative stress
Oxidative Stress - drug effects
Plant Extracts - pharmacology
Polyphenols
Prevention
Proteins
Reactive oxygen species
Red algae
ROS
Science
Soy products
Squamous cell carcinoma
Tumor cell lines
γ-H2AX
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Summary:Methanolic extracts of Gracilaria tenuistipitata (MEGT) were obtained from the edible red algae. Previously, we found that water extract of G. tenuistipitata was able to modulate oxidative stress-induced DNA damage and its related cellular responses. In this study, the methanol extraction product MEGT was used to evaluate the cell growth inhibition in oral cancer cells and its possible mechanism was investigated. The cell viability of MEGT treated Ca9-22 oral cancer cell line was significantly decreased in a dose-response manner (p 
ISSN:1472-6882
1472-6882
DOI:10.1186/1472-6882-12-142