Preparation and Application in Drug Storage and Delivery of Agarose Nanoparticles

In this work, monodisperse agarose gel nanoparticles were prepared using a W/O microemulsion as a template to control the size of the obtained particles. The combination of this template method with a temperature-induced gelling and a solvent exchange methodology has allowed preparing stable aqueous...

Full description

Saved in:
Bibliographic Details
Published in:International journal of polymer science 2018-01, Vol.2018 (2018), p.1-9
Main Authors: Rubio, Ramón G., Lucia, Alejandro, Guzman, Eduardo, Argudo, Pablo G., Ortega, Francisco
Format: Article
Language:English
Subjects:
Aqueous solutions
Biodegradability
Biopolymers
Drug delivery systems
Encapsulation
Environmental impact
Gelation
Hydrogels
Insecticides
Methods
Microemulsions
Nanoparticles
Pharmaceutical sciences
Proteins
Solvents
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this work, monodisperse agarose gel nanoparticles were prepared using a W/O microemulsion as a template to control the size of the obtained particles. The combination of this template method with a temperature-induced gelling and a solvent exchange methodology has allowed preparing stable aqueous dispersions of monodisperse agarose gel nanoparticles in water. The average size, measured as an apparent hydrodynamic diameter, of the obtained particles was around 150 nm. The ability of the obtained hydrogel particles for the encapsulation and release of a synthetic insecticide (azamethiphos) was tested. The results evidence that the insecticide molecules encapsulated in the fabricated nanoparticles are released following a diffusion-controlled mechanism. These results combined with the biodegradability of the agarose provide the bases for the design of a new vector with application in the control of parasites in water reservoirs.
ISSN:1687-9422
1687-9430
DOI:10.1155/2018/7823587