Influence of stimulus frequency on blockade induced by pancuronium and rocuronium: study on rats phrenic nerve-diaphragm preparation Influência da freqüência de estímulos no bloqueio neuromuscular produzido pelo pancurônio e rocurônio: estudo em preparação nervo frênico-diafragma de ratos

PURPOSE: To evaluate the influence of two stimulation frequencies on the installation of neuromuscular blockade produced by pancuronium and rocuronium on the rat diaphragm. METHODS: Diaphragms were submitted to an indirect frequency stimulation of 0.1 and 1Hz (Groups I and II, respectively). Subgrou...

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Bibliographic Details
Published in:Acta cirúrgica brasileira 2007-12, Vol.22 (6), p.446-450
Main Authors: Angélica de Fátima de Assunção Braga, Derli Conceição Munoz, Franklin Sarmento da Silva Braga, Daniele Ribeiro de Araujo, Glória Maria Braga Potério, Mario Mantovani
Format: Article
Language:English
Subjects:
Agentes não Despolarizantes Neuromusculares
Bloqueadores neuromusculares
Diafragma
Diaphragm
Electric Stimulation
Estimulação Elétrica
Nervo Frênico
Neuromuscular Blocking Agents
Neuromuscular nondepolarizing agents
Phrenic Nerve
Ratos
Rats
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Summary:PURPOSE: To evaluate the influence of two stimulation frequencies on the installation of neuromuscular blockade produced by pancuronium and rocuronium on the rat diaphragm. METHODS: Diaphragms were submitted to an indirect frequency stimulation of 0.1 and 1Hz (Groups I and II, respectively). Subgroups were formed (n=5) according to the neuromuscular blocker employed (pancuronium-2µg/ml and rocuronium-4µg/ml). The twitch height depression was evaluated at 5, 15 and 30 minutes after adding the neuromuscular blocker. RESULTS: The decrease in twitch height was greater (p
ISSN:0102-8650
1678-2674
DOI:10.1590/S0102-86502007000600006