The Effect of Alkyl Chain Number in Sucrose Surfactant on the Physical Properties of Quercetin-Loaded Deformable Nanoliposome and Its Effect on In Vitro Human Skin Penetration

Non-invasive skin penetration of a drug is increased by an edge activator, which enhances the nanoliposome deformability. The objective of this study was to investigate the role of the alkyl chain number of sucrose surfactants as an edge activator in elastic nanoliposomes. In addition, the physicoch...

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Published in:Nanomaterials (Basel, Switzerland) Switzerland), 2018-08, Vol.8 (8), p.622
Main Authors: Hong, In Ki, Ha, Ji Hoon, Han, Sangkeun, Kang, Hakhee, Park, Soo Nam
Format: Article
Language:English
Subjects:
Chains
Cosmetics industry
Deformability
Deformation effects
Drug delivery
Drug delivery systems
edge activator
Elastic deformation
elastic nanoliposome
Elastic properties
Elasticity
Entrapment
Formability
Hydration
Ingredients
Lipids
Microscopy
Morphology
Particle size
Penetration
Permeability
Permeability tests
Physical properties
Physicochemical properties
Quercetin
Skin
skin drug delivery system
Skin tests
Sucrose
sucrose stearate
Sugar
Surfactants
Thin films
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cited_by cdi_FETCH-LOGICAL-c475t-3bf42b5f98140c274303cf5f0a6453494ea26f4a27fad79e51de16c5acaf43033
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creator Hong, In Ki
Ha, Ji Hoon
Han, Sangkeun
Kang, Hakhee
Park, Soo Nam
description Non-invasive skin penetration of a drug is increased by an edge activator, which enhances the nanoliposome deformability. The objective of this study was to investigate the role of the alkyl chain number of sucrose surfactants as an edge activator in elastic nanoliposomes. In addition, the physicochemical properties of the elastic nanoliposomes were characterized and an in vitro human skin permeation study was performed. Elastic nanoliposomes that were composed of sucrose monostearate (MELQ), sucrose distearate (DELQ), and sucrose tristearte (TELQ) were prepared using a thin-film hydration method. Particle size and entrapment efficiency of elastic nanoliposomes increased proportionally with an increase in the amounts and the numbers of the stearate in sucrose surfactant. Deformability of elastic nanoliposomes was indicated as DELQ > MELQ > TELQ and the same pattern was revealed through the in vitro human skin permeability tests. These results suggest that the number of alkyl chains of sucrose surfactant as edge activator affects the physicochemical property, stability, and skin permeability in elastic nanoliposome. Our findings give a valuable platform for the development of elastic nanoliposomes as skin drug delivery systems.
doi_str_mv 10.3390/nano8080622
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subjects Chains
Cosmetics industry
Deformability
Deformation effects
Drug delivery
Drug delivery systems
edge activator
Elastic deformation
elastic nanoliposome
Elastic properties
Elasticity
Entrapment
Formability
Hydration
Ingredients
Lipids
Microscopy
Morphology
Particle size
Penetration
Permeability
Permeability tests
Physical properties
Physicochemical properties
Quercetin
Skin
skin drug delivery system
Skin tests
Sucrose
sucrose stearate
Sugar
Surfactants
Thin films
title The Effect of Alkyl Chain Number in Sucrose Surfactant on the Physical Properties of Quercetin-Loaded Deformable Nanoliposome and Its Effect on In Vitro Human Skin Penetration
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