Evaluation of phage—antibiotic combinations in the treatment of extended-spectrum β-lactamase-producing Salmonella enteritidis strain PT1

Foodborne infections caused by Salmonella spp. are among the most common foodborne diseases in the world. We isolated a lytic phage against extended-spectrum beta-lactam producing S. Enteritidis strain PT1 derived from chicken carcass. Results from electronmicrography indicated that phiPT1 belonged...

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Bibliographic Details
Published in:Heliyon 2023-01, Vol.9 (1), p.e13077-e13077, Article e13077
Main Authors: Alharbi, Mona G., Al-Hindi, Rashad R., Alotibi, Ibrahim A., Azhari, Sheren A., Farsi, Reem M., Teklemariam, Addisu D.
Format: Article
Language:English
Subjects:
Extended-spectrum beta-lactamase
Phage antibiotic synergism
Salmonella enteritidis
Siphoviridae phage
Wastewater
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Summary:Foodborne infections caused by Salmonella spp. are among the most common foodborne diseases in the world. We isolated a lytic phage against extended-spectrum beta-lactam producing S. Enteritidis strain PT1 derived from chicken carcass. Results from electronmicrography indicated that phiPT1 belonged to the family, Siphoviridae, in the order, Caudovirales. Phage phiPT1 was stable at temperatures from 4 °C to 60 °C and inactivated at 90 °C. phiPT1 retained a high titer from pH 4 to pH 10 for at least 1 h. Nevertheless, it displayed a significant decrease (p 
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2023.e13077