Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness

Male-pattern baldness (MPB) is a common and highly heritable trait characterized by androgen-dependent, progressive hair loss from the scalp. Here, we carry out the largest GWAS meta-analysis of MPB to date, comprising 10,846 early-onset cases and 11,672 controls from eight independent cohorts. We i...

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Published in:Nature communications 2017-03, Vol.8 (1), p.14694-14694, Article 14694
Main Authors: Heilmann-Heimbach, Stefanie, Herold, Christine, Hochfeld, Lara M., Hillmer, Axel M., Nyholt, Dale R., Hecker, Julian, Javed, Asif, Chew, Elaine G. Y., Pechlivanis, Sonali, Drichel, Dmitriy, Heng, Xiu Ting, del Rosario, Ricardo C. -H., Fier, Heide L., Paus, Ralf, Rueedi, Rico, Galesloot, Tessel E., Moebus, Susanne, Anhalt, Thomas, Prabhakar, Shyam, Li, Rui, Kanoni, Stavroula, Papanikolaou, George, Kutalik, Zoltán, Deloukas, Panos, Philpott, Michael P., Waeber, Gérard, Spector, Tim D., Vollenweider, Peter, Kiemeney, Lambertus A. L. M., Dedoussis, George, Richards, J. Brent, Nothnagel, Michael, Martin, Nicholas G., Becker, Tim, Hinds, David A., Nöthen, Markus M.
Format: Article
Language:English
Subjects:
3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics
38/39
45
45/43
631/208/205/2138
631/208/212
Adipogenesis - genetics
Alopecia - genetics
Androgens
Baldness
Biology
Case-Control Studies
Dentistry
Epidemiology
Fibroblast Growth Factor 5 - genetics
Genetic Association Studies
Genome-Wide Association Study
Genomes
Genomics
Genotype
Hair loss
Health care
Health sciences
Hospitals
Humanities and Social Sciences
Humans
Intercellular Signaling Peptides and Proteins - genetics
Interferon Regulatory Factors - genetics
Male
Medical research
Melatonin
Membrane Proteins - genetics
Meta-analysis
multidisciplinary
Oncology
Phenotype
Preventive medicine
Prostate cancer
Science
Science (multidisciplinary)
Signal Transduction - genetics
Trans-Activators - genetics
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Summary:Male-pattern baldness (MPB) is a common and highly heritable trait characterized by androgen-dependent, progressive hair loss from the scalp. Here, we carry out the largest GWAS meta-analysis of MPB to date, comprising 10,846 early-onset cases and 11,672 controls from eight independent cohorts. We identify 63 MPB-associated loci ( P
ISSN:2041-1723
2041-1723
DOI:10.1038/ncomms14694