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Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness
Male-pattern baldness (MPB) is a common and highly heritable trait characterized by androgen-dependent, progressive hair loss from the scalp. Here, we carry out the largest GWAS meta-analysis of MPB to date, comprising 10,846 early-onset cases and 11,672 controls from eight independent cohorts. We i...
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| Published in: | Nature communications 2017-03, Vol.8 (1), p.14694-14694, Article 14694 |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| creator | Heilmann-Heimbach, Stefanie Herold, Christine Hochfeld, Lara M. Hillmer, Axel M. Nyholt, Dale R. Hecker, Julian Javed, Asif Chew, Elaine G. Y. Pechlivanis, Sonali Drichel, Dmitriy Heng, Xiu Ting del Rosario, Ricardo C. -H. Fier, Heide L. Paus, Ralf Rueedi, Rico Galesloot, Tessel E. Moebus, Susanne Anhalt, Thomas Prabhakar, Shyam Li, Rui Kanoni, Stavroula Papanikolaou, George Kutalik, Zoltán Deloukas, Panos Philpott, Michael P. Waeber, Gérard Spector, Tim D. Vollenweider, Peter Kiemeney, Lambertus A. L. M. Dedoussis, George Richards, J. Brent Nothnagel, Michael Martin, Nicholas G. Becker, Tim Hinds, David A. Nöthen, Markus M. |
| description | Male-pattern baldness (MPB) is a common and highly heritable trait characterized by androgen-dependent, progressive hair loss from the scalp. Here, we carry out the largest GWAS meta-analysis of MPB to date, comprising 10,846 early-onset cases and 11,672 controls from eight independent cohorts. We identify 63 MPB-associated loci (
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| doi_str_mv | 10.1038/ncomms14694 |
| format | article |
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P
<5 × 10
−8
, METAL) of which 23 have not been reported previously. The 63 loci explain ∼39% of the phenotypic variance in MPB and highlight several plausible candidate genes (
FGF5
,
IRF4
,
DKK2
) and pathways (melatonin signalling, adipogenesis) that are likely to be implicated in the key-pathophysiological features of MPB and may represent promising targets for the development of novel therapeutic options. The data provide molecular evidence that rather than being an isolated trait, MPB shares a substantial biological basis with numerous other human phenotypes and may deserve evaluation as an early prognostic marker, for example, for prostate cancer, sudden cardiac arrest and neurodegenerative disorders.
Male-pattern baldness is a common condition in which hair is progressively lost from the scalp. Here, the authors find 23 new genetic variants associated with this condition and suggest that it is not an isolated trait but may share an underlying biological basis with various diseases.</description><identifier>ISSN: 2041-1723</identifier><identifier>EISSN: 2041-1723</identifier><identifier>DOI: 10.1038/ncomms14694</identifier><identifier>PMID: 28272467</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics ; 38/39 ; 45 ; 45/43 ; 631/208/205/2138 ; 631/208/212 ; Adipogenesis - genetics ; Alopecia - genetics ; Androgens ; Baldness ; Biology ; Case-Control Studies ; Dentistry ; Epidemiology ; Fibroblast Growth Factor 5 - genetics ; Genetic Association Studies ; Genome-Wide Association Study ; Genomes ; Genomics ; Genotype ; Hair loss ; Health care ; Health sciences ; Hospitals ; Humanities and Social Sciences ; Humans ; Intercellular Signaling Peptides and Proteins - genetics ; Interferon Regulatory Factors - genetics ; Male ; Medical research ; Melatonin ; Membrane Proteins - genetics ; Meta-analysis ; multidisciplinary ; Oncology ; Phenotype ; Preventive medicine ; Prostate cancer ; Science ; Science (multidisciplinary) ; Signal Transduction - genetics ; Trans-Activators - genetics</subject><ispartof>Nature communications, 2017-03, Vol.8 (1), p.14694-14694, Article 14694</ispartof><rights>The Author(s) 2017</rights><rights>Copyright Nature Publishing Group Mar 2017</rights><rights>Copyright © 2017, The Author(s) 2017 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-807e13288412a0e52543f0185f8599eed48361a0eb715ce4cd9b099a77f37e0d3</citedby><cites>FETCH-LOGICAL-c512t-807e13288412a0e52543f0185f8599eed48361a0eb715ce4cd9b099a77f37e0d3</cites><orcidid>0000-0002-6713-2214 ; 0000-0001-9251-070X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1875124358/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1875124358?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28272467$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heilmann-Heimbach, Stefanie</creatorcontrib><creatorcontrib>Herold, Christine</creatorcontrib><creatorcontrib>Hochfeld, Lara M.</creatorcontrib><creatorcontrib>Hillmer, Axel M.</creatorcontrib><creatorcontrib>Nyholt, Dale R.</creatorcontrib><creatorcontrib>Hecker, Julian</creatorcontrib><creatorcontrib>Javed, Asif</creatorcontrib><creatorcontrib>Chew, Elaine G. Y.</creatorcontrib><creatorcontrib>Pechlivanis, Sonali</creatorcontrib><creatorcontrib>Drichel, Dmitriy</creatorcontrib><creatorcontrib>Heng, Xiu Ting</creatorcontrib><creatorcontrib>del Rosario, Ricardo C. -H.</creatorcontrib><creatorcontrib>Fier, Heide L.</creatorcontrib><creatorcontrib>Paus, Ralf</creatorcontrib><creatorcontrib>Rueedi, Rico</creatorcontrib><creatorcontrib>Galesloot, Tessel E.</creatorcontrib><creatorcontrib>Moebus, Susanne</creatorcontrib><creatorcontrib>Anhalt, Thomas</creatorcontrib><creatorcontrib>Prabhakar, Shyam</creatorcontrib><creatorcontrib>Li, Rui</creatorcontrib><creatorcontrib>Kanoni, Stavroula</creatorcontrib><creatorcontrib>Papanikolaou, George</creatorcontrib><creatorcontrib>Kutalik, Zoltán</creatorcontrib><creatorcontrib>Deloukas, Panos</creatorcontrib><creatorcontrib>Philpott, Michael P.</creatorcontrib><creatorcontrib>Waeber, Gérard</creatorcontrib><creatorcontrib>Spector, Tim D.</creatorcontrib><creatorcontrib>Vollenweider, Peter</creatorcontrib><creatorcontrib>Kiemeney, Lambertus A. L. M.</creatorcontrib><creatorcontrib>Dedoussis, George</creatorcontrib><creatorcontrib>Richards, J. Brent</creatorcontrib><creatorcontrib>Nothnagel, Michael</creatorcontrib><creatorcontrib>Martin, Nicholas G.</creatorcontrib><creatorcontrib>Becker, Tim</creatorcontrib><creatorcontrib>Hinds, David A.</creatorcontrib><creatorcontrib>Nöthen, Markus M.</creatorcontrib><title>Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness</title><title>Nature communications</title><addtitle>Nat Commun</addtitle><addtitle>Nat Commun</addtitle><description>Male-pattern baldness (MPB) is a common and highly heritable trait characterized by androgen-dependent, progressive hair loss from the scalp. Here, we carry out the largest GWAS meta-analysis of MPB to date, comprising 10,846 early-onset cases and 11,672 controls from eight independent cohorts. We identify 63 MPB-associated loci (
P
<5 × 10
−8
, METAL) of which 23 have not been reported previously. The 63 loci explain ∼39% of the phenotypic variance in MPB and highlight several plausible candidate genes (
FGF5
,
IRF4
,
DKK2
) and pathways (melatonin signalling, adipogenesis) that are likely to be implicated in the key-pathophysiological features of MPB and may represent promising targets for the development of novel therapeutic options. The data provide molecular evidence that rather than being an isolated trait, MPB shares a substantial biological basis with numerous other human phenotypes and may deserve evaluation as an early prognostic marker, for example, for prostate cancer, sudden cardiac arrest and neurodegenerative disorders.
Male-pattern baldness is a common condition in which hair is progressively lost from the scalp. Here, the authors find 23 new genetic variants associated with this condition and suggest that it is not an isolated trait but may share an underlying biological basis with various diseases.</description><subject>3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics</subject><subject>38/39</subject><subject>45</subject><subject>45/43</subject><subject>631/208/205/2138</subject><subject>631/208/212</subject><subject>Adipogenesis - genetics</subject><subject>Alopecia - genetics</subject><subject>Androgens</subject><subject>Baldness</subject><subject>Biology</subject><subject>Case-Control Studies</subject><subject>Dentistry</subject><subject>Epidemiology</subject><subject>Fibroblast Growth Factor 5 - genetics</subject><subject>Genetic Association Studies</subject><subject>Genome-Wide Association Study</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Genotype</subject><subject>Hair loss</subject><subject>Health care</subject><subject>Health sciences</subject><subject>Hospitals</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Intercellular Signaling Peptides and Proteins - genetics</subject><subject>Interferon Regulatory Factors - genetics</subject><subject>Male</subject><subject>Medical research</subject><subject>Melatonin</subject><subject>Membrane Proteins - genetics</subject><subject>Meta-analysis</subject><subject>multidisciplinary</subject><subject>Oncology</subject><subject>Phenotype</subject><subject>Preventive medicine</subject><subject>Prostate cancer</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Signal Transduction - genetics</subject><subject>Trans-Activators - genetics</subject><issn>2041-1723</issn><issn>2041-1723</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptks1vFCEUwCdGY5vak3dD4sVER_lc4GLSNH40qfGiZ8Iwb2ZZGdgC22T_e7Fbm62RC4T34_ce8LruJcHvCWbqQ3RpWQrhK82fdKcUc9ITSdnTo_VJd17KBrfBNFGcP-9OqKKS8pU87W6-QbW9jTbsiy_IjxCrnzwUFNMtBJR9-YVCch7ZOKK9hzAWVPalwmKrd8jH4ud1bSdjTaiuAQ0-hTTvUZrQYgP0W1sr5IgGG8YIpbzonk02FDi_n8-6n58__bj82l9__3J1eXHdO0Fo7RWWQBhVihNqMQgqOJswUWJSQmuAkSu2Ii0ySCIccDfqAWttpZyYBDyys-7q4B2T3Zht9ovNe5OsN3cbKc_G5naFAGbUduJcAiimm4ho6piTDDMxNZVkzfXx4NruhgVG1x4p2_BI-jgS_drM6dYIxrm-E7y5F-R0s4NSzeKLgxBshLQrhigpOJZYioa-_gfdpF1uH3SgCOVMqEa9PVAup1IyTA_FEGz-dIY56oxGvzqu_4H92wcNeHcASgvFGfJR0v_4fgNmL8UZ</recordid><startdate>20170308</startdate><enddate>20170308</enddate><creator>Heilmann-Heimbach, Stefanie</creator><creator>Herold, Christine</creator><creator>Hochfeld, Lara M.</creator><creator>Hillmer, Axel M.</creator><creator>Nyholt, Dale R.</creator><creator>Hecker, Julian</creator><creator>Javed, Asif</creator><creator>Chew, Elaine G. 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Brent</creatorcontrib><creatorcontrib>Nothnagel, Michael</creatorcontrib><creatorcontrib>Martin, Nicholas G.</creatorcontrib><creatorcontrib>Becker, Tim</creatorcontrib><creatorcontrib>Hinds, David A.</creatorcontrib><creatorcontrib>Nöthen, Markus M.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Nature communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heilmann-Heimbach, Stefanie</au><au>Herold, Christine</au><au>Hochfeld, Lara M.</au><au>Hillmer, Axel M.</au><au>Nyholt, Dale R.</au><au>Hecker, Julian</au><au>Javed, Asif</au><au>Chew, Elaine G. Y.</au><au>Pechlivanis, Sonali</au><au>Drichel, Dmitriy</au><au>Heng, Xiu Ting</au><au>del Rosario, Ricardo C. -H.</au><au>Fier, Heide L.</au><au>Paus, Ralf</au><au>Rueedi, Rico</au><au>Galesloot, Tessel E.</au><au>Moebus, Susanne</au><au>Anhalt, Thomas</au><au>Prabhakar, Shyam</au><au>Li, Rui</au><au>Kanoni, Stavroula</au><au>Papanikolaou, George</au><au>Kutalik, Zoltán</au><au>Deloukas, Panos</au><au>Philpott, Michael P.</au><au>Waeber, Gérard</au><au>Spector, Tim D.</au><au>Vollenweider, Peter</au><au>Kiemeney, Lambertus A. L. M.</au><au>Dedoussis, George</au><au>Richards, J. Brent</au><au>Nothnagel, Michael</au><au>Martin, Nicholas G.</au><au>Becker, Tim</au><au>Hinds, David A.</au><au>Nöthen, Markus M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness</atitle><jtitle>Nature communications</jtitle><stitle>Nat Commun</stitle><addtitle>Nat Commun</addtitle><date>2017-03-08</date><risdate>2017</risdate><volume>8</volume><issue>1</issue><spage>14694</spage><epage>14694</epage><pages>14694-14694</pages><artnum>14694</artnum><issn>2041-1723</issn><eissn>2041-1723</eissn><abstract>Male-pattern baldness (MPB) is a common and highly heritable trait characterized by androgen-dependent, progressive hair loss from the scalp. Here, we carry out the largest GWAS meta-analysis of MPB to date, comprising 10,846 early-onset cases and 11,672 controls from eight independent cohorts. We identify 63 MPB-associated loci (
P
<5 × 10
−8
, METAL) of which 23 have not been reported previously. The 63 loci explain ∼39% of the phenotypic variance in MPB and highlight several plausible candidate genes (
FGF5
,
IRF4
,
DKK2
) and pathways (melatonin signalling, adipogenesis) that are likely to be implicated in the key-pathophysiological features of MPB and may represent promising targets for the development of novel therapeutic options. The data provide molecular evidence that rather than being an isolated trait, MPB shares a substantial biological basis with numerous other human phenotypes and may deserve evaluation as an early prognostic marker, for example, for prostate cancer, sudden cardiac arrest and neurodegenerative disorders.
Male-pattern baldness is a common condition in which hair is progressively lost from the scalp. Here, the authors find 23 new genetic variants associated with this condition and suggest that it is not an isolated trait but may share an underlying biological basis with various diseases.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28272467</pmid><doi>10.1038/ncomms14694</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-6713-2214</orcidid><orcidid>https://orcid.org/0000-0001-9251-070X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2041-1723 |
| ispartof | Nature communications, 2017-03, Vol.8 (1), p.14694-14694, Article 14694 |
| issn | 2041-1723 2041-1723 |
| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_d9af447ee8394cd192c3c73035f7e073 |
| source | Publicly Available Content Database; Nature; PubMed Central; Springer Nature - nature.com Journals - Fully Open Access |
| subjects | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics 38/39 45 45/43 631/208/205/2138 631/208/212 Adipogenesis - genetics Alopecia - genetics Androgens Baldness Biology Case-Control Studies Dentistry Epidemiology Fibroblast Growth Factor 5 - genetics Genetic Association Studies Genome-Wide Association Study Genomes Genomics Genotype Hair loss Health care Health sciences Hospitals Humanities and Social Sciences Humans Intercellular Signaling Peptides and Proteins - genetics Interferon Regulatory Factors - genetics Male Medical research Melatonin Membrane Proteins - genetics Meta-analysis multidisciplinary Oncology Phenotype Preventive medicine Prostate cancer Science Science (multidisciplinary) Signal Transduction - genetics Trans-Activators - genetics |
| title | Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness |
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