Biocompatibility and Transplantation Efficacy of the C-Clear Artificial Cornea in a Rabbit Chemical Burn Model

We investigated the bioavailability and stability of a C-Clear artificial cornea in a rabbit chemical burn model. Thirty-six rabbits were divided into a control group ( = 16) and a chemical burn group that used NaOH solution ( = 20). After lamellar dissection, the central posterior lamella was excis...

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Bibliographic Details
Published in:Bioengineering (Basel) 2023-10, Vol.10 (10), p.1235
Main Authors: Chung, Ho-Seok, Nam, Sanghyu, Lee, Ko-Eun, Jeong, Do-Sun, Oh, Seheon, Sunwoo, Jeong-Hye, Lee, Hun, Kim, Jae-Yong, Tchah, Hungwon
Format: Article
Language:English
Subjects:
Animals
artificial cornea
Bioavailability
Biocompatibility
Bioengineering
Burns and scalds
C-Clear
Cornea
Corneal transplantation
Evaluation
Iris
Laboratories
Lamella
Lasers
Lee, J.H
Membranes
Neodymium lasers
Neomycin
Physiological aspects
rabbit chemical corneal burn model
Rabbits
retroprosthetic membrane
Semiconductor lasers
Sodium hydroxide
Structural stability
Transplantation
YAG lasers
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Summary:We investigated the bioavailability and stability of a C-Clear artificial cornea in a rabbit chemical burn model. Thirty-six rabbits were divided into a control group ( = 16) and a chemical burn group that used NaOH solution ( = 20). After lamellar dissection, the central posterior lamella was excised using a 3 mm diameter trephine, and an artificial cornea was transplanted into the lamellar pocket. After 2 weeks, the central anterior lamella was excised using a 3 mm diameter trephine to secure a clean visual axis. We examined the anterior segment of the eyes weekly for 12 weeks after transplantation. Successful subjects whose artificial corneas were maintained stably for 12 weeks were euthanized and underwent histologic examinations. Artificial corneas remained stable for up to 12 weeks in 62.5 and 50% of rabbits in the control and chemical burn groups, respectively. Two rabbits in the chemical burn group showed the formation of a retroprosthetic membrane, and one rabbit with visual axis blockage underwent membrane removal using a Nd:YAG laser. In histologic examinations, adhesion between artificial cornea and peripheral corneal stoma was observed. In conclusion, we confirmed structural stability and biocompatibility of the C-Clear artificial cornea for up to 12 weeks after implantation in control and chemical burn groups.
ISSN:2306-5354
2306-5354
DOI:10.3390/bioengineering10101235