Classification of tic disorders based on functional MRI by machine learning: a study protocol

IntroductionTic disorder (TD) is a common neurodevelopmental disorder in children, and it can be categorised into three subtypes: provisional tic disorder (PTD), chronic motor or vocal TD (CMT or CVT), and Tourette syndrome (TS). An early diagnostic classification among these subtypes is not possibl...

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Bibliographic Details
Published in:BMJ open 2022-05, Vol.12 (5), p.e047343-e047343
Main Authors: Wang, Fang, Wen, Fang, Liu, Jingran, Yan, Junjuan, Yu, Liping, Li, Ying, Cui, Yonghua
Format: Article
Language:English
Subjects:
Accuracy
Child & adolescent psychiatry
Classification
Hospitals
Machine learning
Medical imaging
Mental disorders
Neuroimaging
Paediatrics
Protocols & guidelines
PSYCHIATRY
Radiomics
Schizophrenia
Support vector machines
Teenagers
Tourette syndrome
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Summary:IntroductionTic disorder (TD) is a common neurodevelopmental disorder in children, and it can be categorised into three subtypes: provisional tic disorder (PTD), chronic motor or vocal TD (CMT or CVT), and Tourette syndrome (TS). An early diagnostic classification among these subtypes is not possible based on a new-onset tic symptom. Machine learning tools have been widely used for early diagnostic classification based on functional MRI (fMRI). However, few machine learning models have been built for the diagnostic classification of patients with TD. Therefore, in the present study, we will provide a study protocol that uses the machine learning model to make early classifications of the three different types of TD.Methods and analysisWe planned to recruit 200 children aged 6–9 years with new-onset tic symptoms and 100 age-matched and sex-matched healthy controls under resting-state MRI scanning. Based on the neuroimaging data of resting-state fMRI, the support vector machine (SVM) model will be built. We planned to construct an SVM model based on functional connectivity for the early diagnosis classification of TD subtypes (including PTD, CMT/CVT, TS).Ethics and disseminationThis study was approved by the ethics committee of Beijing Children’s Hospital. The trial results will be submitted to peer-reviewed journals for publication.Trial registration numberChiCTR2000033257.
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2020-047343