Morphological Studies Of Placenta Of Mouse (Balb/C) Addicted To Heroin

• Published in: Majallah-i Danishkadah-'i Pizishki 2003-06, Vol.61 (1), p.57-63
• Main Authors: Tootian Z, Fazeli Poor S, Kiani S B
• Format: Article
• Language: per
• Subjects: Mous; Placenta
• ISSN: 1683-1764; 1735-7322

In this research, the effects of heroin in the placenta of addicted mouse were studied properly."nMethods and Materials: For this reason we used of addicted female mice before, during and after gestation and also a control group of healthy mice. The male mice were in two groups of addicted and healthy. Heroin were used in concentration of 0.1, 0.3 and 0.5 mg/ml in tap water. Placenta of mice separated from uterus in 17th days of gestation and compared with placenta of non addicted mice, with diameter, weight and abnormal conformations."nResults: The results showed that there were significant comparison between diameters and weights of these two groups (p<0.0001). In morphological studies, there were changes in size (small placenta, giant placenta), joining and hemorhagic state placentas."nConclusion: According to the results we concluded that the opioids even with with very small doses can induce harmful effects on gestation and non-pure heroin in Iranian smugglery is much more harmful than the pure one.