Short-term heart rate variability as a predictor of long-term survival in patients with chronic hemodialysis: A prospective cohort study

Heart rate variability (HRV), a non-invasive measurement of the sympathetic-vagal balance, has been demonstrated as a predictor of long-term survival in various patient populations. However, its predictive value in patients with end-stage renal disease (ESRD) has not been evaluated in a long-term fo...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the Formosan Medical Association 2018-12, Vol.117 (12), p.1058-1064
Main Authors: Kuo, George, Chen, Szi-Wen, Huang, Jeng-Yi, Wu, Chao-Yi, Fu, Chung-Ming, Chang, Chih-Hsiang, Liu, Su-Hsun, Chan, Yi-Hsin, Wu, I-Wen, Yang, Huang-Yu
Format: Article
Language:English
Subjects:
Aged
Cardiorenal syndrome
Electrocardiography
End-stage renal disease
Female
Follow-Up Studies
Heart Rate
Heart rate variability
Hemodialysis
Humans
Kidney Failure, Chronic - mortality
Kidney Failure, Chronic - therapy
Male
Middle Aged
Prognosis
Proportional Hazards Models
Prospective Studies
Renal Dialysis - mortality
Survival
Taiwan - epidemiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Heart rate variability (HRV), a non-invasive measurement of the sympathetic-vagal balance, has been demonstrated as a predictor of long-term survival in various patient populations. However, its predictive value in patients with end-stage renal disease (ESRD) has not been evaluated in a long-term follow-up study. Prospective data collected for 41 patients with chronic hemodialysis (age 59 ± 10 years, men 51.3%, diabetes mellitus 31%, and duration of dialysis 64 ± 50 months) who underwent a 5-minute electrocardiogram (ECG) recording as a baseline for frequency domain HRV analysis. During a median follow-up of 150.2 months from 2003 to 2014, 15 (35.7%) patients died (3 due to cardiac causes and 12 due to non-cardiac causes). The Cox proportional hazards model suggested that the low frequency versus high frequency signal (LF/HF) of a high ratio for the HRV and diabetes mellitus were two independent predictors of mortality (hazard ratios 3.028 and 3.494; p = 0.033 and 0.022, respectively). Less reduction in MAP during dialysis showed borderline significance of long-term survival than those with larger drop (p = 0.058). A short ECG recording and an analysis of the frequency domain of the HRV is clinically predictive of the long-term survival of patients with chronic hemodialysis.
ISSN:0929-6646
1876-0821
DOI:10.1016/j.jfma.2018.09.006