Parotid gland MALT lymphoma with amyloid deposition, challenges in preoperative diagnosis: A case report

Mucosa-associated lymphoid tissue (MALT) lymphoma commonly arises from chronic inflammation or autoimmune diseases, such as Sjögren syndrome (SjS). Although rare, amyloid deposition in MALT lymphoma has been reported. We present a rare case of parotid gland MALT lymphoma in a 49-year-old woman, in w...

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Bibliographic Details
Published in:Radiology case reports 2024-12, Vol.19 (12), p.6141-6146
Main Authors: Watanabe, Yuriko, Fujii, Hiroyuki, Yamamoto, Saki, Masuoka, Sota, Kobayashi, Ryoma, Fujii, Nana, Nakamata, Akihiro, Kanazawa, Takeharu, Matsuki, Mitsuru, Mori, Harushi
Format: Article
Language:English
Subjects:
Amyloidosis
Case Report
MALT lymphoma
MRI
Parotid gland
Sjögren syndrome
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Summary:Mucosa-associated lymphoid tissue (MALT) lymphoma commonly arises from chronic inflammation or autoimmune diseases, such as Sjögren syndrome (SjS). Although rare, amyloid deposition in MALT lymphoma has been reported. We present a rare case of parotid gland MALT lymphoma in a 49-year-old woman, in whom preoperative diagnosis was challenging due to atypical imaging findings resulting from amyloid deposits. MRI showed T2-hypointense and T1-iso- to slightly hyperintense masses in the left parotid gland and right sublingual gland, with predominant marginal contrast enhancement and no significant diffusion restriction. Additionally, atrophy and fatty replacement of the parenchyma were noted in bilateral parotid glands, suggesting SjS. Left superficial parotidectomy was performed and pathological findings confirmed MALT lymphoma with extensive amyloid deposition. Histopathological findings of the resected parotid gland parenchyma also suggested SjS. MALT lymphoma should be considered in the differential diagnosis of multiple salivary gland masses in patients with suspected SjS. If MRI reveals atypical imaging findings for malignant lymphoma, particularly T2-hypointensity with no significant diffusion restriction, the possibility of amyloid deposition in MALT lymphoma should be considered.
ISSN:1930-0433
1930-0433
DOI:10.1016/j.radcr.2024.09.083