Sensitive detection of exhaled breath condensate inflammation biomarkers using boron nitride nanosheet/gold nanoparticle hybrids

An ultrasensitive electrochemical immunosensor using boron nitride nanosheet/gold nanoparticle (BNNS/AuNP) hybrids was developed for exhaled breath condensate (EBC) interleukin-6 (IL-6) quantification. BNNS were synthesized by chemical vapor deposition and decorated with AuNPs. The BNNS/AuNP hybrids...

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Bibliographic Details
Published in:Alexandria engineering journal 2024-04, Vol.93, p.280-287
Main Authors: Zhang, Jing, Li, Fanming, Yang, Yang, Cheng, Deyun
Format: Article
Language:English
Subjects:
Boron nitride nanosheets
Electrochemical immunosensor
Exhaled breath condensate
Gold nanoparticles
Nanocomposite
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Summary:An ultrasensitive electrochemical immunosensor using boron nitride nanosheet/gold nanoparticle (BNNS/AuNP) hybrids was developed for exhaled breath condensate (EBC) interleukin-6 (IL-6) quantification. BNNS were synthesized by chemical vapor deposition and decorated with AuNPs. The BNNS/AuNP hybrids were characterized by SEM, TEM, XRD, Raman, XPS, etc., and deposited on screen-printed carbon electrodes. Anti-IL-6 antibodies were immobilized via EDC/NHS crosslinking. The immunosensor detected IL-6 by differential pulse voltammetry technique with a linear range of 0.01–200 ng/mL and a limit of detection of 5 pg/mL. The sensor showed high reproducibility and selectivity. Validation with spiked EBC samples demonstrated good accuracy (relative error
ISSN:1110-0168
DOI:10.1016/j.aej.2024.03.019