The Impact of Combined Warm and Cold Ischemia Time on Post-transplant Outcomes

Background: Prolonged warm ischemia time (WIT) and cold ischemia time (CIT) are independently associated with post-transplant graft failure; their combined impact has not been previously studied. We explored the effect of combined WIT/CIT on all-cause graft failure following kidney transplantation....

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Bibliographic Details
Published in:Canadian journal of kidney health and disease 2023-01, Vol.10, p.20543581231178960-20543581231178960
Main Authors: Foley, Martha E., Vinson, Amanda J., Skinner, Thomas A. A., Kiberd, Bryce A., Tennankore, Karthik K.
Format: Article
Language:English
Subjects:
Ischemia
Original Basic Research
Transplants & implants
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Summary:Background: Prolonged warm ischemia time (WIT) and cold ischemia time (CIT) are independently associated with post-transplant graft failure; their combined impact has not been previously studied. We explored the effect of combined WIT/CIT on all-cause graft failure following kidney transplantation. Methods: The Scientific Registry of Transplant Recipients was used to identify kidney transplant recipients from January 2000 to March 2015 (after which WIT was no longer separately reported), and patients were followed until September 2017. A combined WIT/CIT variable (excluding extreme values) was separately derived for live and deceased donor recipients using cubic splines; for live donor recipients, the reference group was WIT 10 to 0 to
ISSN:2054-3581
2054-3581
DOI:10.1177/20543581231178960