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TNF-α and IL-6 as biomarkers of impaired lung functions in dimethylacetamide exposure

Tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) are well-known biomarkers of systemic inflammation that have been associated with many diseases in the past. In this study, we aimed to determine the relationship between impaired lung functions and the levels of these biomarkers in DMAc expos...

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Published in:Journal of medical biochemistry 2019-07, Vol.38 (3), p.276-283
Main Authors: Tutkun, Lütfiye, İritaş, Servet Birgin, Deniz, Serdar, Öztan, Özgür, Abuşoğlu, Sedat, Ünlü, Ali, Türksoy, Vugar Ali, Çetintepe, Sultan Pınar
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container_title Journal of medical biochemistry
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creator Tutkun, Lütfiye
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Çetintepe, Sultan Pınar
description Tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) are well-known biomarkers of systemic inflammation that have been associated with many diseases in the past. In this study, we aimed to determine the relationship between impaired lung functions and the levels of these biomarkers in DMAc exposed people. 101 non-exposed control subjects (Group 1) and 109 DMAc-exposed workers from the polyvinyl chloride (PVC) industry were included in the study. In the next step, the exposed group was divided into two groups according to the level of exposure (Group 2 and 3). DMAc, TNF-α, IL-6, creatinine, ALT, AST, GFR and standard spirometry measurements were carried out in all subjects. When compared to the control group, TNF-α and IL-6 levels were significantly high compatible with the increase of DMAc levels, in the exposed groups. Urinary DMAc Levels were 0.06 mg/L in the control group. This level is significantly low when compared to exposed and severely exposed group (2.43 mg/L and 3.17 mg/L). TNF-α levels were 56.86 pg/mL, 145.52 pg/mL and 230.52 pg/mL in control, exposed and severely exposed groups. IL-6 levels were found to be 38.08 pg/mL, 89.19 pg/mL and 116 pg/mL for control, exposed and severely exposed groups, respectively. Similarly, the FEV1/FVC ratio decreased especially in the severely exposed group (p 0.001). In our study, results have revealed that TNF-and IL-6 levels are promising biomarkers in the early diagnosis of lung function impairment in inhalational DMAc exposure.
doi_str_mv 10.2478/jomb-2018-0040
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In this study, we aimed to determine the relationship between impaired lung functions and the levels of these biomarkers in DMAc exposed people. 101 non-exposed control subjects (Group 1) and 109 DMAc-exposed workers from the polyvinyl chloride (PVC) industry were included in the study. In the next step, the exposed group was divided into two groups according to the level of exposure (Group 2 and 3). DMAc, TNF-α, IL-6, creatinine, ALT, AST, GFR and standard spirometry measurements were carried out in all subjects. When compared to the control group, TNF-α and IL-6 levels were significantly high compatible with the increase of DMAc levels, in the exposed groups. Urinary DMAc Levels were 0.06 mg/L in the control group. This level is significantly low when compared to exposed and severely exposed group (2.43 mg/L and 3.17 mg/L). TNF-α levels were 56.86 pg/mL, 145.52 pg/mL and 230.52 pg/mL in control, exposed and severely exposed groups. IL-6 levels were found to be 38.08 pg/mL, 89.19 pg/mL and 116 pg/mL for control, exposed and severely exposed groups, respectively. Similarly, the FEV1/FVC ratio decreased especially in the severely exposed group (p 0.001). 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subjects Biomarkers
Control methods
Creatinine
dimethylacetamide (dm ac)
dimethylacetamide (DMAc)
dimetilacetamid (DMAc)
Exposure
faktor tumorske nekroze-α (TNF-α)
Interleukin 6
interleukin-6 (IL-6)
Levels
Lungs
Occupational exposure
Original Paper
plućni kapaciteti
Polyvinyl chloride
pulmonary capacities
Respiratory function
toksično udisanje
toxic inhalation
Tumor necrosis factor-TNF
Tumor necrosis factor-α
tumour necrosis factor-α (TNF-α)
title TNF-α and IL-6 as biomarkers of impaired lung functions in dimethylacetamide exposure
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