Age at type 2 diabetes diagnosis and the risk of mortality among US population

To examine the relationship between age at diagnosis of type 2 diabetes (T2DM) with cardiovascular and all-cause mortality in the U.S. population. Data was used from NHANES 1999 ~ 2018, which were screened to include a total of 8,654 participants with a diagnosis of diabetes for the study. We estima...

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Bibliographic Details
Published in:Scientific reports 2024-11, Vol.14 (1), p.29155-12, Article 29155
Main Authors: Zhang, Hong-Jin, Feng, Jie, Zhang, Xiang-Tao, Zhang, Hong-Zhou
Format: Article
Language:English
Subjects:
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Adult
Age
Age Factors
Age of Onset
Aged
Cardiovascular diseases
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - mortality
Cause of Death
Death
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - mortality
Diagnosis
Female
Health risks
Humanities and Social Sciences
Humans
Male
Middle Aged
Mortality
Mortality risk
multidisciplinary
Nutrition Surveys
Obesity
Population studies
Proportional Hazards Models
Risk Factors
Science
Science (multidisciplinary)
Sensitivity analysis
Survival
Type 2
United States - epidemiology
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Summary:To examine the relationship between age at diagnosis of type 2 diabetes (T2DM) with cardiovascular and all-cause mortality in the U.S. population. Data was used from NHANES 1999 ~ 2018, which were screened to include a total of 8,654 participants with a diagnosis of diabetes for the study. We estimated the association between age at diagnosis and cardiovascular and all-cause mortality using weighted multivariate Cox regression analyses. Subgroup analyses and sensitivity analyses were performed to ensure the robustness of the data analysis. The number of participants diagnosed with diabetes at ages  60 are 1,492, 3,970, and 3,192, respectively, with median ages of 44.04, 57.59, and 72.24. Among patients diagnosed with T2DM, the relative risk of all-cause mortality increased with younger age at diagnosis: compared to patients with late-onset diabetes (age at type 2 diabetes diagnosis ≥ 60), the hazard ratio for all-cause mortality was 2.72 (95% CI 1.83–4.05) in those with early-onset diabetes (age at type 2 diabetes diagnosis 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-80790-8