Magnetic Hyperthermia Nanoarchitectonics via Iron Oxide Nanoparticles Stabilised by Oleic Acid: Anti-Tumour Efficiency and Safety Evaluation in Animals with Transplanted Carcinoma

In this study, we developed iron oxide nanoparticles stabilised with oleic acid/sodium oleate that could exert therapeutic effects for curing tumours via magnetic hyperthermia. A suspension of iron oxide nanoparticles was produced and characterised. The toxicity of the synthesised composition was ex...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-04, Vol.23 (8), p.4234
Main Authors: Kulikov, Oleg A, Zharkov, Mikhail N, Ageev, Valentin P, Yakobson, Denis E, Shlyapkina, Vasilisa I, Zaborovskiy, Andrey V, Inchina, Vera I, Balykova, Larisa A, Tishin, Alexander M, Sukhorukov, Gleb B, Pyataev, Nikolay A
Format: Article
Language:English
Subjects:
Acids
Animals
anti-tumour activity
Biocompatibility
Carcinoma
Cytotoxicity
Evaluation
Fever
Heat
Hyperthermia
Hyperthermia, Induced - methods
iron oxide nanoparticles
Iron oxides
Magnetic Fields
magnetic hyperthermia
Magnetite
Magnetite Nanoparticles - chemistry
Magnetite Nanoparticles - therapeutic use
Nanoparticles
Oleic Acid
Organs
Sodium oleate
Toxicity
Tumors
W256 carcinoma
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Summary:In this study, we developed iron oxide nanoparticles stabilised with oleic acid/sodium oleate that could exert therapeutic effects for curing tumours via magnetic hyperthermia. A suspension of iron oxide nanoparticles was produced and characterised. The toxicity of the synthesised composition was examined in vivo and found to be negligible. Histological examination showed a low local irritant effect and no effect on the morphology of the internal organs. The efficiency of magnetic hyperthermia for the treatment of transplanted Walker 256 carcinoma was evaluated. The tumour was infiltrated with the synthesised particles and then treated with an alternating magnetic field. The survival rate was 85% in the studied therapy group of seven animals, while in the control group (without treatment), all animals died. The physicochemical and pharmaceutical properties of the synthesised fluid and the therapeutic results, as seen in the in vivo experiments, provide insights into therapeutic hyperthermia using injected magnetite nanoparticles.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23084234