Systemic Inflammation after Aneurysmal Subarachnoid Hemorrhage

Aneurysmal subarachnoid hemorrhage (aSAH) is one of the most severe neurological disorders, with a high mortality rate and severe disabling functional sequelae. Systemic inflammation following hemorrhagic stroke may play an important role in mediating intracranial and extracranial tissue damage. Pre...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-06, Vol.24 (13), p.10943
Main Authors: Chai, Chang-Zhang, Ho, Ue-Cheung, Kuo, Lu-Ting
Format: Article
Language:English
Subjects:
Aneurysm
Antigens
Biomarkers
Catecholamines
cerebral aneurysm
Chemokines
Clinical trials
Complications
Consciousness
Cytokines
Dexmedetomidine
Diseases
Edema
Flow velocity
Health aspects
Hemodynamics
Hemoglobin
Hemorrhage
Hemorrhagic Stroke
Humans
Immune system
Inflammation
Inflammation - complications
Intracranial Aneurysm - complications
Ischemia
Magnetic resonance imaging
Metabolites
Mortality
Nervous system
Neurological diseases
Neutrophils
Nosocomial infections
Review
Stroke
Stroke (Disease)
Subarachnoid hemorrhage
Subarachnoid Hemorrhage - etiology
systemic inflammation
Transcription factors
Trauma
Traumatic brain injury
Tumor necrosis factor-TNF
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Description
Summary:Aneurysmal subarachnoid hemorrhage (aSAH) is one of the most severe neurological disorders, with a high mortality rate and severe disabling functional sequelae. Systemic inflammation following hemorrhagic stroke may play an important role in mediating intracranial and extracranial tissue damage. Previous studies showed that various systemic inflammatory biomarkers might be useful in predicting clinical outcomes. Anti-inflammatory treatment might be a promising therapeutic approach for improving the prognosis of patients with aSAH. This review summarizes the complicated interactions between the nervous system and the immune system.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms241310943