Helicobacter pylori infection in humans and phytotherapy, probiotics, and emerging therapeutic interventions: a review

The global prevalence of infection remains high, indicating a persistent presence of this pathogenic bacterium capable of infecting humans. This review summarizes the population demographics, transmission routes, as well as conventional and novel therapeutic approaches for infection. The prevalence...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in microbiology 2024-01, Vol.14, p.1330029
Main Authors: Liu, Mengkai, Gao, Hui, Miao, Jinlai, Zhang, Ziyan, Zheng, Lili, Li, Fei, Zhou, Sen, Zhang, Zhiran, Li, Shengxin, Liu, He, Sun, Jie
Format: Article
Language:English
Subjects:
Helicobacter pylori
infection mechanism
infection population
Microbiology
phytotherapy
probiotics
transmission routes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The global prevalence of infection remains high, indicating a persistent presence of this pathogenic bacterium capable of infecting humans. This review summarizes the population demographics, transmission routes, as well as conventional and novel therapeutic approaches for infection. The prevalence of infection exceeds 30% in numerous countries worldwide and can be transmitted through interpersonal and zoonotic routes. Cytotoxin-related gene A (CagA) and vacuolar cytotoxin A (VacA) are the main virulence factors of , contributing to its steep global infection rate. Preventative measures should be taken from people's living habits and dietary factors to reduce infection. Phytotherapy, probiotics therapies and some emerging therapies have emerged as alternative treatments for infection, addressing the issue of elevated antibiotic resistance rates. Plant extracts primarily target urease activity and adhesion activity to treat , while probiotics prevent infection through both immune and non-immune pathways. In the future, the primary research focus will be on combining multiple treatment methods to effectively eradicate infection.
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2023.1330029