Tissue-specific profiling of age-dependent miRNAomic changes in Caenorhabditis elegans

Ageing exhibits common and distinct features in various tissues, making it critical to decipher the tissue-specific ageing mechanisms. MiRNAs are essential regulators in ageing and are recently highlighted as a class of intercellular messengers. However, little is known about the tissue-specific tra...

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Published in:Nature communications 2024-02, Vol.15 (1), p.955-955, Article 955
Main Authors: Wang, Xueqing, Jiang, Quanlong, Zhang, Hongdao, He, Zhidong, Song, Yuanyuan, Chen, Yifan, Tang, Na, Zhou, Yifei, Li, Yiping, Antebi, Adam, Wu, Ligang, Han, Jing-Dong J., Shen, Yidong
Format: Article
Language:English
Subjects:
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Aging
Body wall
Extracellular vesicles
Forkhead protein
Humanities and Social Sciences
Intestine
MicroRNAs
miRNA
multidisciplinary
Science
Science (multidisciplinary)
Tissues
Transcriptomics
Vesicles
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Summary:Ageing exhibits common and distinct features in various tissues, making it critical to decipher the tissue-specific ageing mechanisms. MiRNAs are essential regulators in ageing and are recently highlighted as a class of intercellular messengers. However, little is known about the tissue-specific transcriptomic changes of miRNAs during ageing. C. elegans is a well-established model organism in ageing research. Here, we profile the age-dependent miRNAomic changes in five isolated worm tissues. Besides the diverse ageing-regulated miRNA expression across tissues, we discover numerous miRNAs in the tissues without their transcription. We further profile miRNAs in the extracellular vesicles and find that worm miRNAs undergo inter-tissue trafficking via these vesicles in an age-dependent manner. Using these datasets, we uncover the interaction between body wall muscle-derived mir-1 and DAF-16/FOXO in the intestine, suggesting mir-1 as a messenger in inter-tissue signalling. Taken together, we systematically investigate worm miRNAs in the somatic tissues and extracellular vesicles during ageing, providing a valuable resource to study tissue-autonomous and nonautonomous functions of miRNAs in ageing. Wang et al. profile age-dependent miRNAomic changes in worm tissues and extracellular vesicles (EVs). They show that ageing controls miRNAs in a tissue-specific manner and their findings further suggest a complex EV-mediated miRNA trafficking network across tissues.
ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-024-45249-4