Customized flexible hollow microneedles for psoriasis treatment with reduced‐dose drug

Microneedles, especially hollow microneedles (HMNs), play an important role in drug delivery, but most of the current HMNs are manufactured based on silicon microfabrication (lithography, etching, etc.), which are slightly conservative due to the lack of low‐cost, batch‐scale and customized preparat...

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Bibliographic Details
Published in:Bioengineering & translational medicine 2023-07, Vol.8 (4), p.e10530-n/a
Main Authors: Ren, Yingjie, Li, Junshi, Chen, Yiwen, Wang, Jing, Chen, Yuxuan, Wang, Zhongyan, Zhang, Zhitong, Chen, Yufeng, Shi, Xiaoyi, Cao, Lu, Zhang, Jiayan, Dong, Huang, Yan, Cong, Li, Zhihong
Format: Article
Language:English
Subjects:
3-D printers
Biocompatibility
Biomedical materials
Curing
Customization
Diameters
drug delivery
Drug dosages
dual‐molding process
Efficiency
Flexibility
hollow microneedles
Injection molding
Mechanical properties
Molding (process)
Molds
Morphology
Needles
Polymers
Psoriasis
Side effects
Software
Substrates
Three dimensional printing
Toxicity
Viscosity
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Summary:Microneedles, especially hollow microneedles (HMNs), play an important role in drug delivery, but most of the current HMNs are manufactured based on silicon microfabrication (lithography, etching, etc.), which are slightly conservative due to the lack of low‐cost, batch‐scale and customized preparation approach, especially for the HMNs with flexible substrate. For the first time, we propose the use of a high‐precision 3D printed master mold followed by a dual‐molding process for the preparation of HMNs with different shapes, heights, and inner and outer diameters to satisfy different drug delivery needs. The 3D printed master mold and negative mold can be reused, thereby significantly reducing the cost. HMNs are based on biocompatible materials, such as heat‐curing polymers or light‐curing resins. The thickness and rigidity/flexibility characteristics of the substrate can be customized for different applications. The drug delivery efficiency of the fabricated HMNs was verified by the in situ treatment of psoriasis on the backs of mice, which required only a 0.1‐fold oral dose to achieve similar efficacy, and the associated side effects and drug toxicity were reduced. Thus, this dual‐molding process can reinvigorate HMNs development.
ISSN:2380-6761
2380-6761
DOI:10.1002/btm2.10530