P05-09. 4e10 epitope-scaffolds mimic the antibody-bound epitope conformation and block neutralization by sera from rare HIV+ individuals

Meeting abstracts - A single PDF containing all abstracts in this Supplement is available at http://www.biomedcentral.com/content/files/pdf/1742-4690-6-S3-full.pdf.EMPTY Background A protective vaccine against HIV will likely require elicitation of potent broadly neutralizing antibodies as well as c...

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Published in:Retrovirology 2009-10, Vol.6 (Suppl 3), p.P85-P85, Article P85
Main Authors: Ban, YA, Correia, BE, Holmes, M, Boni, E, Sather, N, Bretz, C, Kalyuzhniy, O, Xu, C, Baker, D, Stamatatos, L, Strong, R, Schief, W
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
AIDS
Crystal structure
HIV
Human immunodeficiency virus
Medical research
Poster Presentation
Online Access:Get full text
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Summary:Meeting abstracts - A single PDF containing all abstracts in this Supplement is available at http://www.biomedcentral.com/content/files/pdf/1742-4690-6-S3-full.pdf.EMPTY Background A protective vaccine against HIV will likely require elicitation of potent broadly neutralizing antibodies as well as cellular immunity. mAb 4e10 has the greatest breadth of the known neutralizing monoclonal antibodies, but 4e10-like antibodies are rarely elicited in natural infection.
ISSN:1742-4690
1742-4690
DOI:10.1186/1742-4690-6-S3-P85