The indicator of clinical outcomes for patients with heterotopic pregnancy following in-vitro fertilization with embryo transfer

• Published in: Taiwanese journal of obstetrics & gynecology 2019-11, Vol.58 (6), p.827-832
• Main Authors: Shang, Jianhong, Peng, Ruan, Zheng, Ju, Lin, Meifang
• Format: Article
• Language: English
• Subjects: Clinical outcomes; Heterotopic pregnancy; Independent predictor; Transvaginal sonography
• ISSN: 1028-4559
• DOI: 10.1016/j.tjog.2019.09.018

To explore the early predictors for pregnancy outcomes in patients with heterotopic pregnancy (HP) following in-vitro fertilization with embryo transfer (IVF-ET). This retrospective study reviewed 81 patients with HP following IVF-ET in our institution between January 2003 and September 2017. The relationships between clinical outcomes and general characteristics, sonographic features and different management options were analyzed by logistic regression analysis. The gestational age at the time of diagnosis was 50.9 ± 12.3 days. Among these cases, 76 were accurately diagnosed by TVS, 1 was misdiagnosed as adnexal torsion by TVS, and 4 were confirmed to have IUPs after the surgical treatment. Hence, the sensitivity of TVS for detecting HP was 93.8% (76/81). However, forty-seven patients (58.0%) had suspected HP when they underwent the initial TVS. Among these patients, live births occurred for 60 patients, 11 of whom delivered preterm. The miscarriage rate was 58.3% (14/24) for patients without IUP cardiac activity at HP diagnosis, and 12.3% (7/57) for patients with IUP cardiac activity; a significant correlation was identified (χ2 = 18.651, P