A Proposal for the Interpretation of Serum IGF-I Concentration as Part of Laboratory Screening in Children with Growth Failure

The serum insulin-like growth factor-I (IGF-I) concentration is commonly used as a screening tool for growth hormone deficiency (GHD), but there is no consensus on the cut-off limit of IGF-I standard deviation score (SDS) to perform GH stimulation tests for confirmation or exclusion of GHD. We argue...

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Bibliographic Details
Published in:Journal of clinical research in pediatric endocrinology 2020-06, Vol.12 (2), p.130-139
Main Authors: Wit, Jan M., Bidlingmaier, Martin, de Bruin, Christiaan, Oostdijk, Wilma
Format: Article
Language:English
Subjects:
Adolescent
Adult
Child
Child, Preschool
Female
growth disorders
Growth Disorders - blood
Growth Disorders - diagnosis
Humans
igf-i
igfbp-3
Insulin-Like Growth Factor Binding Protein 3 - blood
Insulin-Like Growth Factor I - metabolism
Male
Netherlands
Pediatrics - standards
Reference Standards
Review
short stature
Societies, Medical - standards
Tıp
Young Adult
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Description
Summary:The serum insulin-like growth factor-I (IGF-I) concentration is commonly used as a screening tool for growth hormone deficiency (GHD), but there is no consensus on the cut-off limit of IGF-I standard deviation score (SDS) to perform GH stimulation tests for confirmation or exclusion of GHD. We argue that the cut-off limit is dependent on the clinical pre-test likelihood of GHD and propose a diagnostic strategy in which the cut-off limit varies between zero to -2 SDS.
ISSN:1308-5727
1308-5735
DOI:10.4274/jcrpe.galenos.2019.2019.0176