Nephroprotective Activity of Papaloquelite ( Porophyllum ruderale ) in Thioacetamide-Induced Injury Model

Acute kidney injury and impaired kidney function is associated with reduced survival and increased morbidity. is an edible plant endemic to Mexico used in Mexican traditional medicine. The aim of this study was to evaluate the nephroprotective effect of a hydroalcoholic extract (MeOH:water 70:30, )...

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Published in:Plants (Basel) 2022-12, Vol.11 (24), p.3460
Main Authors: Vázquez-Atanacio, María José, Bautista, Mirandeli, González-Cortazar, Manasés, Romero-Estrada, Antonio, De la O-Arciniega, Minarda, Castañeda-Ovando, Araceli, Sosa-Gutiérrez, Carolina G, Ojeda-Ramírez, Deyanira
Format: Article
Language:English
Subjects:
anti-inflammatory
Anti-inflammatory agents
Anti-inflammatory drugs
antioxidant
Antioxidants
Bilirubin
Biomarkers
Chemical properties
Compositae
Control
Creatinine
Cytokines
Diuretics
Endemic plants
Free radicals
Glucosides
Hemoglobin
In vivo methods and tests
Inflammation
Injury prevention
Kaempferol
Ketones
Kidney diseases
Kidneys
Leukocytes
Lipopolysaccharides
Liquid chromatography
Macrophages
Medicinal plants
Morbidity
nephroprotective
Nitric oxide
Nitrites
Oxidative stress
Pharmaceutical research
Porophyllum ruderale
Quercetin
Specific gravity
Thioacetamide
Urea
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Summary:Acute kidney injury and impaired kidney function is associated with reduced survival and increased morbidity. is an edible plant endemic to Mexico used in Mexican traditional medicine. The aim of this study was to evaluate the nephroprotective effect of a hydroalcoholic extract (MeOH:water 70:30, ) from the aerial parts of (HEPr). Firstly, in vitro the antioxidant and anti-inflammatory activity of HEPr was determined; after the in vivo nephroprotective activity of HEPr was evaluated using a thioacetamide-induced injury model in rats. HEPr showed a slight effect on LPS-NO production in macrophages (15% INO at 40 µg/mL) and high antioxidant activity in the ferric reducing antioxidant power (FRAP) test, followed by the activity on DPPH and ABTS radicals test (69.04, 63.06 and 32.96% of inhibition, respectively). In addition, values of kidney injury biomarkers in urine (urobilinogen, hemoglobin, bilirubin, ketones, glucose, protein, pH, nitrites, leukocytes, specific gravity, and the microalbumin/creatinine) and serum (creatinine, urea, and urea nitrogen) of rats treated with HEPr were maintained in normal ranges. Finally, 5- -caffeoylquinic, 4- -caffeoylquinic and ferulic acids; as well as 3- -quercetin glucoside and 3- -kaempferol glucoside were identified by HPLC as major components of HEPr. In conclusion, constitutes a source of compounds for the treatment of acute kidney injury.
ISSN:2223-7747
2223-7747
DOI:10.3390/plants11243460