Fe65: A Scaffolding Protein of Actin Regulators

The scaffolding protein family Fe65, composed of Fe65, Fe65L1, and Fe65L2, was identified as an interaction partner of the amyloid precursor protein (APP), which plays a key function in Alzheimer's disease. All three Fe65 family members possess three highly conserved interaction domains, formin...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2021-06, Vol.10 (7), p.1599
Main Authors: Augustin, Vanessa, Kins, Stefan
Format: Article
Language:English
Subjects:
Actin
Actin Cytoskeleton - metabolism
Actins - metabolism
Alzheimer's disease
Amino acids
Amyloid beta-Protein Precursor - metabolism
Amyloid precursor protein
Animals
Arf6
Axonogenesis
Calcium homeostasis
Calcium metabolism
Cell migration
cortactin
Cytoskeleton
DOCK
ELMO
Gene expression
Homeostasis
Humans
Intracellular signalling
Kinases
Lipid metabolism
Lipoproteins
Mammals
Mena
Models, Biological
Nerve Tissue Proteins - genetics
Nerve Tissue Proteins - metabolism
Neurodegenerative diseases
Physiology
Protein Binding
Proteins
Review
Synaptic plasticity
Tip60
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Summary:The scaffolding protein family Fe65, composed of Fe65, Fe65L1, and Fe65L2, was identified as an interaction partner of the amyloid precursor protein (APP), which plays a key function in Alzheimer's disease. All three Fe65 family members possess three highly conserved interaction domains, forming complexes with diverse binding partners that can be assigned to different cellular functions, such as transactivation of genes in the nucleus, modulation of calcium homeostasis and lipid metabolism, and regulation of the actin cytoskeleton. In this article, we rule out putative new intracellular signaling mechanisms of the APP-interacting protein Fe65 in the regulation of actin cytoskeleton dynamics in the context of various neuronal functions, such as cell migration, neurite outgrowth, and synaptic plasticity.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells10071599