Castleman's disease: an intrapulmonary form with intrafissural development

Castleman's disease (CD) is an uncommon, mainly benign, lymphoproliferative disorder of unknown etiology, mostly involving the mediastinum. Parenchymal lung involvement of the disease is exceedingly rare. We describe a case of CD in a 23-year-old woman with a 4-year history of recurring dyspnea...

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Bibliographic Details
Published in:TheScientificWorld 2009-01, Vol.9, p.940-945
Main Authors: Racil, Hajer, Cheikh Rouhou, Sana, Ismail, Olfa, Hantous-Zannad, Saoussen, Chaouch, Nawel, Zarrouk, Mourad, Smati, Belhassen, Mezni, Faouzi, Chabbou, Abdellatif
Format: Article
Language:English
Subjects:
Case Study
Castleman Disease - diagnosis
Castleman Disease - diagnostic imaging
Castleman Disease - surgery
CT imaging
Development and progression
Female
Humans
Lung - diagnostic imaging
Lung - surgery
Lymphoproliferative disorders
Physiological aspects
Tomography, X-Ray Computed
Young Adult
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Description
Summary:Castleman's disease (CD) is an uncommon, mainly benign, lymphoproliferative disorder of unknown etiology, mostly involving the mediastinum. Parenchymal lung involvement of the disease is exceedingly rare. We describe a case of CD in a 23-year-old woman with a 4-year history of recurring dyspnea and nonproductive cough, whose chest X-ray showed an abnormal shadow of the right hilum. Chest computed tomography confirmed the presence of a tissue-density mass of the right lower lobe, demonstrating poor contrast enhancement, associated with multiple laterotracheal and mediastinal lymphadenopathies. The patient underwent curative surgery, revealing a right hilar compressive mass, with an intrafissural development between the superior and middle lobes. Pneumonectomy was performed due to profuse bleeding. This case of CD is particular because of its unusual intrapulmonary location and its intrafissural development. Poor contrast enhancement is atypical in CD.
ISSN:1537-744X
2356-6140
1537-744X
DOI:10.1100/tsw.2009.110