Iron and oxidizing species in oxidative stress and Alzheimer's disease

Iron species can participate in the Fenton or Fenton‐like reaction to generate oxidizing species that can cause oxidative damages to biomolecules and induce oxidative stress in the body. Furthermore, iron accumulation and oxidative stress have been shown to associate with the pathological progressio...

Full description

Saved in:
Bibliographic Details
Published in:Aging medicine 2019-06, Vol.2 (2), p.82-87
Main Author: Zhao, Zhongwei
Format: Article
Language:English
Subjects:
Alzheimer's disease
Antioxidants
Apoptosis
Catalytic oxidation
Deoxyribonucleic acid
DNA
Enzymes
Fenton/Fenton‐like reaction
Hydrogen peroxide
hydroxyl radical
iron species
Ligands
Lipids
Metals
Mitochondrial DNA
Oxidative stress
Parkinson's disease
Physiology
Proteins
Review
Special Issue: Dementia
Vitamin E
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Iron species can participate in the Fenton or Fenton‐like reaction to generate oxidizing species that can cause oxidative damages to biomolecules and induce oxidative stress in the body. Furthermore, iron accumulation and oxidative stress have been shown to associate with the pathological progression of neurodegenerative disorders, including Alzheimer's disease (AD) and Parkinson's disease (PD). In this review, the role of iron species in generating the most deleterious free radical species (ie, hydroxyl radical) and effects of this species in causing oxidative stress in vivo are described. The implications of oxidative stress and the recently recognized cell death pathway (ie, ferroptosis) to AD are addressed. Strategies to combat this neurodegenerative disease, such as iron chelation and antioxidant therapies, and future research directions on this aspect are also discussed.
ISSN:2475-0360
2475-0360
DOI:10.1002/agm2.12074