Involvement of the SIRT1-NLRP3 pathway in the inflammatory response

The silent information regulator 2 homolog 1-NACHT, LRR and PYD domains-containing protein 3 (SIRT1-NLRP3) pathway has a crucial role in regulation of the inflammatory response, and is closely related to the occurrence and development of several inflammation-related diseases. NLRP3 is activated to p...

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Published in:Cell communication and signaling 2023-07, Vol.21 (1), p.185-185, Article 185
Main Authors: Chen, Huiyue, Deng, Jiayu, Gao, Huan, Song, Yanqing, Zhang, Yueming, Sun, Jingmeng, Zhai, Jinghui
Format: Article
Language:English
Subjects:
Alzheimer's disease
Antioxidants
Arteriosclerosis
Caspase-1
Cytokines
Enzymes
Inflammasomes
Inflammation
Inflammatory response
Interleukin 18
Kinases
LRR and PYD domains-containing protein 3
Melatonin
Metabolism
Mitochondria
NACHT
NF-κB protein
Nuclear factor erythroid 2-related factor 2
Nuclear factor-kappa B
Proteins
Review
SIRT1 protein
Sirtuin 1
Traumatic brain injury
Tumor necrosis factor-TNF
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Summary:The silent information regulator 2 homolog 1-NACHT, LRR and PYD domains-containing protein 3 (SIRT1-NLRP3) pathway has a crucial role in regulation of the inflammatory response, and is closely related to the occurrence and development of several inflammation-related diseases. NLRP3 is activated to produce the NLRP3 inflammasome, which leads to activation of caspase-1 and cleavage of pro-interleukin (IL)-1β and pro-IL-18 to their active forms: IL-1β and IL-18, respectively. They are proinflammatory cytokines which then cause an inflammatory response.SIRT1 can inhibit this inflammatory response through nuclear factor erythroid 2-related factor 2 and nuclear factor-kappa B pathways. This review article focuses mainly on how the SIRT1-NLRP3 pathway influences the inflammatory response and its relationship with melatonin, traumatic brain injury, neuroinflammation, depression, atherosclerosis, and liver damage. Video Abstract.
ISSN:1478-811X
1478-811X
DOI:10.1186/s12964-023-01177-2