Effect and interaction of TNKS genetic polymorphisms and environmental factors on telomere damage in COEs-exposure workers

• Published in: Ecotoxicology and environmental safety 2023-01, Vol.250, p.114489-114489, Article 114489
• Main Authors: Duan, Xiaoran, Huang, Tao, Zhang, Daping, Wei, Yujie, Li, Lifeng, Yao, Wu, Cui, Liuxin, Zhou, Xiaoshan, Yang, Yongli, Wang, Wei, Zhao, Jie
• Format: Article
• Language: English
• Subjects: Coke - adverse effects; Coke Oven Emissions; DNA Damage; Humans; Occupational Exposure - adverse effects; Occupational Exposure - analysis; Polycyclic Aromatic Hydrocarbons - analysis; Polycyclic Aromatic Hydrocarbons - toxicity; Polymorphism, Genetic; Tankyrases - genetics; Telomere - genetics; Telomere Damage; TNKS gene
• ISSN: 0147-6513; 1090-2414
• DOI: 10.1016/j.ecoenv.2022.114489

Coke oven emissions (COEs) contain many carcinogenic polycyclic aromatic hydrocarbons (PAHs). Telomere damage is an early biological marker reflecting long-term COEs-exposure. Whereas, whether the genetic variations of telomere-regulated gene TNKS have an effect on the COEs-induced telomere damage is unknown. So we detected the environmental exposure levels, relative telomere length (RTL), and TNKS genetic polymorphisms among 544 COEs-exposure workers and 238 healthy participants. We found that the RTL of the wild homozygous GG genotype in rs1055328 locus was statistically shorter compared with the CG+CC genotype for the healthy participants using covariance analysis(P = 0.008). In the Generalized linear model (GLM) analysis, TNKS rs1055328 GG could accelerate telomere shortening (P = 0.011); and the interaction between TNKS rs1055328 GG and COEs-exposure had an effect on RTL (P = 0.002). In conclusion, this study was the first to discover the role of TNKS rs1055328 locus in COEs-induced telomere damage, and proved that chromosomal damage was a combined consequence of environmental and genetic factors. •Cumulative exposure dose (CED), and 1-OHPYR were significantly negatively correlated with RTL.•TNKS rs1055328 GG could promote telomere damage.•The interaction between TNKS rs1055328 GG and COEs-exposure had an effect on RTL.